Section of Dermatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Pediatr Dermatol. 2024 Mar-Apr;41(2):275-278. doi: 10.1111/pde.15414. Epub 2023 Sep 8.
Cutaneous warts are an exceedingly common cutaneous viral infection for which existing treatment options are often painful, expensive, and only marginally effective. Extensive warts may occur in the setting of primary immunodeficiencies, wherein they can co-occur with other diseases of immune dysfunction, such as atopic dermatitis (AD). Dupilumab, an IL-4 receptor α (IL-4Rα)-blocking monoclonal antibody, is a biologic agent recently approved for the treatment of moderate-to-severe eczema. Here, we report a case of a young girl with both severe AD and diffuse filiform warts, which resolved shortly after initiating treatment for AD with dupilumab.
皮肤疣是一种极其常见的皮肤病毒感染，现有的治疗方法往往既痛苦又昂贵，而且效果也只是略有改善。广泛的疣可能发生在原发性免疫缺陷的情况下，其中它们可能与其他免疫功能障碍疾病同时发生，如特应性皮炎（AD）。度普利尤单抗是一种 IL-4 受体α（IL-4Rα）阻断单克隆抗体，是一种最近被批准用于治疗中重度特应性皮炎的生物制剂。在这里，我们报告了一例患有严重特应性皮炎和弥漫性丝状疣的年轻女孩的病例，在开始使用度普利尤单抗治疗特应性皮炎后，她的疣很快就消退了。
