Department of Radiology, Lianyungang Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Lianyungang, China.
Department of Neurology, Nanjing Yuhua Hospital, Yuhua Branch of Nanjing First Hospital, Nanjing, China.
CNS Neurosci Ther. 2024 Mar;30(3):e14458. doi: 10.1111/cns.14458. Epub 2023 Sep 8.
Previous studies have suggested that presbycusis (age-related hearing loss) is accompanied with cognitive decline and dementia. However, the neural mechanism underlying the cognitive decline in presbycusis remains unclear. This study aimed to evaluate the glymphatic system function in presbycusis patients compared to healthy controls using diffusion tensor imaging (DTI) with the perivascular space (DTI-ALPS) method.
DTI scans were obtained from 30 presbycusis patients with cognitive decline (PCD), 30 presbycusis patients with no cognitive decline (PNCD) and 40 age-, gender-, and education-matched healthy controls (HCs). The DTI-ALPS index was calculated for each group. We evaluated the differences in the DTI-ALPS index among PCD, PNCD and HCs. In addition, we conducted a correlation analysis between the DTI-ALPS index and cognitive performance.
There were significant differences of the DTI-ALPS index among three groups. Post-hoc analysis suggested that the DTI-ALPS index in PCD was significantly lower patients in relative to PNCD and HCs (1.49147 vs. 1.57441 vs. 1.62020, p < 0.001). After correcting for age, gender, and education, the DTI-ALPS index is positively correlated with the MoCA scores (rho = 0.426, p = 0.026).
Presbycusis patients with cognitive impairment exhibited decreased glymphatic activity than those without cognitive impairment and HCs. The DTI-ALPS index may provide useful disease progression or treatment biomarkers for patients with presbycusis as an indicator of modulation of glymphatic activity.
先前的研究表明， presbycusis（与年龄相关的听力损失）伴随着认知能力下降和痴呆。然而， presbycusis 认知能力下降的神经机制尚不清楚。本研究旨在使用扩散张量成像（DTI）与血管周围空间（DTI-ALPS）方法评估 presbycusis 患者与健康对照组之间的糖质系统功能。
对 30 名认知能力下降的 presbycusis 患者（PCD）、30 名无认知能力下降的 presbycusis 患者（PNCD）和 40 名年龄、性别和教育程度匹配的健康对照组（HCs）进行 DTI 扫描。计算每组的 DTI-ALPS 指数。我们评估了 PCD、PNCD 和 HCs 之间 DTI-ALPS 指数的差异。此外，我们还进行了 DTI-ALPS 指数与认知表现之间的相关性分析。
三组间 DTI-ALPS 指数存在显著差异。事后分析表明，PCD 的 DTI-ALPS 指数明显低于 PNCD 和 HCs（1.49147 比 1.57441 比 1.62020，p<0.001）。在校正年龄、性别和教育后，DTI-ALPS 指数与 MoCA 评分呈正相关（rho=0.426，p=0.026）。
认知障碍的 presbycusis 患者的糖质系统活性低于无认知障碍和 HCs 的患者。DTI-ALPS 指数可能为 presbycusis 患者提供有用的疾病进展或治疗生物标志物，作为糖质系统活性调节的指标。
