Çağlar Yağcı Hanife, Yağcı İlker, Özdamar Osman İlkay, Tosyalı Salman Cansu, Ertuğrul Özlem
Department of Physical Medicine and Rehabilitation, Göztepe Prof. Dr. Süleyman Yalçın City Hospital, Istanbul, Türkiye.
Department of Physical Medicine and Rehabilitation, Marmara University Faculty of Medicine, Istanbul, Türkiye.
Arch Rheumatol. 2023 Apr 24;38(2):257-266. doi: 10.46497/ArchRheumatol.2023.10186. eCollection 2023 Jun.
Hearing loss has been described in patients with radiographic axial spondyloarthropathies (R-AxSpA) but has not been studied in patients with non-radiographic axial spondyloarthropathies (NR-AxSpA); accordingly, the aim of the study was to compare hearing loss in patients with NR-AxSpA, R-AxSpA, and healthy individuals.
This cross-sectional observational study was conducted with 68 participants (30 males, 38 females; mean age: 39.8±7.4 years) between March 2021 and March 2022. Of the participants, 16 were patients with NR-AxSpA, 15 were patients with R-AxSpA, and 37 were healthy controls. Disease activity and radiological and audiological features were analyzed. The audiological assessment included pure-tone audiometric tests at octave frequencies of 250 to 8000 Hz and transient evoked otoacoustic emissions.
Hearing loss was found in three (8%) in the healthy group, five (31.3%) in the NR-AxSpA group, and 10 (66.7%) in the R-AxSpA group. The chi-square analysis showed a statistical significance (p=0.001). Values of audiometric tests yielded significant differences between the control and R-AxSpA group and also the control and NR-AxSpA group. For the air conduction studies, the statistical significance began at 1000 Hz in the R-AxSpA group. It was found that in the NR-AxSpA group, the statistical difference started in higher frequencies. The bone conduction audiometric studies were similar to air conduction studies. Transient evoked otoacoustic emission studies showed that the R-AxSpA group was significantly affected compared to the control and NR-AxSpA groups. There was no statistical difference between the control and NR-AxSpA groups.
Both NR-AxSpA and R-AxSpA patients had hearing loss; however, in pure-tone audiometric tests, the abnormalities began in lower frequencies in the R-AxSpA group than in the NR-AxSpA group.
听力损失在影像学轴向型脊柱关节炎（R-AxSpA）患者中已有报道，但在非影像学轴向型脊柱关节炎（NR-AxSpA）患者中尚未得到研究；因此，本研究的目的是比较NR-AxSpA患者、R-AxSpA患者和健康个体的听力损失情况。
本横断面观察性研究于2021年3月至2022年3月对68名参与者（30名男性，38名女性；平均年龄：39.8±7.4岁）进行。参与者中，16名是NR-AxSpA患者，15名是R-AxSpA患者，37名是健康对照者。分析疾病活动度以及放射学和听力学特征。听力学评估包括在250至8000Hz倍频程频率下的纯音听力测试和瞬态诱发耳声发射测试。
健康组中有3人（8%）出现听力损失，NR-AxSpA组中有5人（31.3%），R-AxSpA组中有10人（66.7%）。卡方分析显示具有统计学意义（p=0.001）。听力测试值在对照组与R-AxSpA组之间以及对照组与NR-AxSpA组之间均产生了显著差异。对于气导研究，R-AxSpA组在1000Hz时开始具有统计学意义。发现在NR-AxSpA组中，统计学差异始于更高频率。骨导听力测试与气导研究相似。瞬态诱发耳声发射研究表明，与对照组和NR-AxSpA组相比，R-AxSpA组受到的影响显著。对照组和NR-AxSpA组之间无统计学差异。
NR-AxSpA患者和R-AxSpA患者均有听力损失；然而，在纯音听力测试中，R-AxSpA组的异常始于比NR-AxSpA组更低的频率。
