• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Epigenetic targeting of myeloid-derived suppressor cells: time to move into infectious diseases?

作者信息

Gjerstorff Morten Frier

机构信息

Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

Department of Oncology, Odense University Hospital, Odense, Denmark.

出版信息

Front Immunol. 2023 Aug 23;14:1247715. doi: 10.3389/fimmu.2023.1247715. eCollection 2023.

DOI:10.3389/fimmu.2023.1247715
PMID:37680643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10482232/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6806/10482232/4817b0703ec7/fimmu-14-1247715-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6806/10482232/4817b0703ec7/fimmu-14-1247715-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6806/10482232/4817b0703ec7/fimmu-14-1247715-g001.jpg

相似文献

1
Epigenetic targeting of myeloid-derived suppressor cells: time to move into infectious diseases?髓源性抑制细胞的表观遗传靶向治疗:是时候进军传染病领域了吗?
Front Immunol. 2023 Aug 23;14:1247715. doi: 10.3389/fimmu.2023.1247715. eCollection 2023.
2
Myeloid-derived suppressor cells (MDSC): When good intentions go awry.髓系来源的抑制细胞(MDSC):好心办坏事。
Cell Immunol. 2021 Apr;362:104302. doi: 10.1016/j.cellimm.2021.104302. Epub 2021 Feb 4.
3
Editorial: The role of epigenetic modification in MDSC differentiation and function.社论:表观遗传修饰在髓系来源抑制细胞分化和功能中的作用
Front Immunol. 2023 Mar 14;14:1177138. doi: 10.3389/fimmu.2023.1177138. eCollection 2023.
4
Epigenetic modifications in the accumulation and function of myeloid-derived suppressor cells.在髓系来源的抑制细胞的积累和功能中的表观遗传修饰。
Front Immunol. 2022 Nov 11;13:1016870. doi: 10.3389/fimmu.2022.1016870. eCollection 2022.
5
Neutrophils and PMN-MDSC: Their biological role and interaction with stromal cells.中性粒细胞和 PMN-MDSC:它们的生物学作用及其与基质细胞的相互作用。
Semin Immunol. 2018 Feb;35:19-28. doi: 10.1016/j.smim.2017.12.004. Epub 2017 Dec 15.
6
Epigenetics in myeloid derived suppressor cells: a sheathed sword towards cancer.髓源性抑制细胞中的表观遗传学:一把指向癌症的双刃剑。
Oncotarget. 2016 Aug 30;7(35):57452-57463. doi: 10.18632/oncotarget.10767.
7
Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis.髓系来源的抑制性细胞功能和表观遗传表达在手术后脓毒症中随时间演变。
Crit Care. 2019 Nov 13;23(1):355. doi: 10.1186/s13054-019-2628-x.
8
The Emerging Role of Myeloid-Derived Suppressor Cells in Tuberculosis.髓系来源抑制细胞在结核病中的新作用。
Front Immunol. 2019 Apr 30;10:917. doi: 10.3389/fimmu.2019.00917. eCollection 2019.
9
Immunosuppressive effects and mechanisms of three myeloid-derived suppressor cells subsets including monocytic-myeloid-derived suppressor cells, granulocytic-myeloid-derived suppressor cells, and immature-myeloid-derived suppressor cells.三种髓系来源的抑制细胞亚群(包括单核细胞-髓系来源的抑制细胞、粒细胞-髓系来源的抑制细胞和未成熟-髓系来源的抑制细胞)的免疫抑制作用及其机制。
J Cancer Res Ther. 2021 Jul-Sep;17(4):1093-1100. doi: 10.4103/jcrt.JCRT_1222_20.
10
Myeloid-Derived Suppressor Cells in Infection: A General Overview.髓源性抑制细胞在感染中的作用:综述。
J Innate Immun. 2018;10(5-6):407-413. doi: 10.1159/000489830. Epub 2018 Jun 26.

引用本文的文献

1
Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition.随机去甲基化和冗余的表观遗传抑制机制产生了对药理学DNA甲基转移酶抑制的高度异质性反应。
J Exp Clin Cancer Res. 2025 Jan 23;44(1):21. doi: 10.1186/s13046-025-03294-x.
2
Increased CD14HLA-DR myeloid-derived suppressor cells can be regarded as a biomarker on disease severity and response to therapy in acute coronary syndrome.在急性冠脉综合征中,髓系来源的抑制性细胞 CD14HLA-DR 的增加可以作为疾病严重程度和治疗反应的生物标志物。
PeerJ. 2024 Oct 8;12:e18154. doi: 10.7717/peerj.18154. eCollection 2024.

本文引用的文献

1
Inhibition of myeloid-derived suppressor cell arginase-1 production enhances T-cell-based immunotherapy against Cryptococcus neoformans infection.抑制髓源抑制细胞精氨酸酶-1 的产生可增强基于 T 细胞的免疫疗法对抗新型隐球菌感染。
Nat Commun. 2022 Jul 14;13(1):4074. doi: 10.1038/s41467-022-31723-4.
2
Myeloid-Derived Suppressor Cells: The Expanding World of Helminth Modulation of the Immune System.髓源性抑制细胞:寄生虫对免疫系统调节作用的广阔世界。
Front Immunol. 2022 Jun 10;13:874308. doi: 10.3389/fimmu.2022.874308. eCollection 2022.
3
DNA hypomethylating agents increase activation and cytolytic activity of CD8 T cells.
DNA 去甲基化剂增加 CD8 T 细胞的激活和细胞毒性活性。
Mol Cell. 2021 Apr 1;81(7):1469-1483.e8. doi: 10.1016/j.molcel.2021.01.038. Epub 2021 Feb 19.
4
Cancer Epigenetics, Tumor Immunity, and Immunotherapy.癌症表观遗传学、肿瘤免疫与免疫治疗。
Trends Cancer. 2020 Jul;6(7):580-592. doi: 10.1016/j.trecan.2020.02.003. Epub 2020 Mar 31.
5
The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer.DNA 甲基转移酶抑制剂,地西他滨,通过靶向肿瘤诱导的骨髓细胞生成,并与过继免疫疗法相结合,恢复 T 细胞活性,从而减缓乳腺癌小鼠模型中的肿瘤生长。
BMC Immunol. 2020 Feb 27;21(1):8. doi: 10.1186/s12865-020-0337-5.
6
Epigenetic therapy inhibits metastases by disrupting premetastatic niches.表观遗传学治疗通过破坏前转移龛来抑制转移。
Nature. 2020 Mar;579(7798):284-290. doi: 10.1038/s41586-020-2054-x. Epub 2020 Feb 26.
7
MDSCs in infectious diseases: regulation, roles, and readjustment.感染性疾病中的髓系抑制细胞:调控、作用及再调整。
Cancer Immunol Immunother. 2019 Apr;68(4):673-685. doi: 10.1007/s00262-018-2277-y. Epub 2018 Dec 19.
8
Myeloid-Derived Suppressor Cells in Infection: A General Overview.髓源性抑制细胞在感染中的作用:综述。
J Innate Immun. 2018;10(5-6):407-413. doi: 10.1159/000489830. Epub 2018 Jun 26.
9
Myeloid-derived suppressor cells coming of age.髓系来源的抑制细胞崭露头角。
Nat Immunol. 2018 Feb;19(2):108-119. doi: 10.1038/s41590-017-0022-x. Epub 2018 Jan 18.
10
Differential Regulation of Myeloid-Derived Suppressor Cells by Species.不同物种对髓系来源抑制细胞的差异性调控
Front Microbiol. 2016 Oct 13;7:1624. doi: 10.3389/fmicb.2016.01624. eCollection 2016.