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某些苯乙胺对用3H-多巴胺预标记的离体大鼠尾状核放射性释放影响的比较。

A comparison of the effects of some phenethylamines on the release of radioactivity from isolated rat caudate nucleus prelabelled with 3H-dopamine.

作者信息

Kalix P

出版信息

Arzneimittelforschung. 1986 Jul;36(7):1019-21.

PMID:3768065
Abstract

In order to evaluate a series of phenethylamines with regard to their capacity to induce release from presynaptic catecholamine stores, their effect on the efflux of radioactivity from 3H-dopamine-prelabelled rat caudate nucleus tissue was determined. All of the phenethylamines studied were found to enhance the release of radioactivity from this preparation. However, marked differences were observed between the individual compounds with regard to potency and dose dependence of the effect.

摘要

为了评估一系列苯乙胺从突触前儿茶酚胺储存库诱导释放的能力,测定了它们对3H-多巴胺预标记的大鼠尾状核组织放射性流出的影响。研究发现,所有研究的苯乙胺都能增强该制剂中放射性的释放。然而,在各个化合物之间,在效力和效应的剂量依赖性方面观察到明显差异。

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A comparison of the effects of some phenethylamines on the release of radioactivity from isolated rat caudate nucleus prelabelled with 3H-dopamine.某些苯乙胺对用3H-多巴胺预标记的离体大鼠尾状核放射性释放影响的比较。
Arzneimittelforschung. 1986 Jul;36(7):1019-21.
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