Davidson B C, Cantrill R C, Kurstjens N P, Patton J
Department of Medical Biochemistry, University of the Witwatersrand Medical School, Johannesburg, South Africa.
In Vivo. 1988 May-Aug;2(3-4):295-8.
A classical neurotransmitter release model was used to investigate the effect of the limitation of dietary polyenoic fatty acids on the function of presynaptic dopamine autoreceptors in slices from the caudate nucleus of kittens (juvenile domestic cats). Maximum inhibition of 3H-dopamine release was detected only in the brains of animals receiving post delta-6-desaturation fatty acids of both the omega 3 and omega 6 series. The removal of either, or both, groups of fatty acids resulted in attenuation of sensitivity of the autoreceptor to apomorphine. It would appear that omega 6 fatty acids are more important for a normal pattern of dopaminergic function to be established in the caudate nucleus of kittens.
采用经典的神经递质释放模型，研究膳食多不饱和脂肪酸受限对幼猫（幼年家猫）尾状核切片中突触前多巴胺自身受体功能的影响。仅在摄入ω-3和ω-6系列Δ-6-去饱和后脂肪酸的动物大脑中检测到3H-多巴胺释放的最大抑制。去除其中一组或两组脂肪酸会导致自身受体对阿扑吗啡的敏感性降低。看来，ω-6脂肪酸对于幼猫尾状核中建立正常的多巴胺能功能模式更为重要。
