Severiche-Bueno Diego Fernando, Ramirez Sandra Ximena, Vargas-Cuervo María Teresa, Bueno David Felipe Severiche, Navarro Carmelo Jiménez, Mugnier Jacqueline, Rodriguez Juan Pablo
MD, MSc, Universidad de La Sabana, Chía, Cundinamarca, KM 7.5 Autopista Norte de Bogotá, Chía, Colombia.
MD, Universidad del Rosario, Bogotá D.C, Colombia, Calle 163A # 13B - 60 Bogotá, Colombia.
Germs. 2022 Sep 30;12(3):409-413. doi: 10.18683/germs.2022.1346. eCollection 2022 Sep.
Actinomycosis is an unusual chronic granulomatous infectious disease. They are commensals in various sites of the human body but with little pathogenicity. is the most prevalent species but more than 30 species have been described. Infection of the lower respiratory tract is unusual, the involvement of mediastinum being even rarer.
A 63-year-old man, previously healthy and living in a rural area, presented with a 5-month history of hemoptysis, pleuritic pain, weight loss, and night sweats. Community-acquired pneumonia with a mediastinal mass was documented, for which he received antibiotic management. Thoracoscopy was carried out for diagnosis and resection of the mediastinal mass due to inconclusive findings in the percutaneous biopsy. Pathology reported the presence of filamentous Gram-positive bacteria visible in Grocott staining. Due to the pathology findings, and the fact that no other infectious agents were identified, a diagnosis of actinomycosis was established. Treatment with oral amoxicillin 1g TID for 6 months was initiated.
As far as we are aware, we present the sixth case of mediastinal actinomycosis. We present this case to bring attention to this rare but clinically relevant presentation to be considered as a differential diagnosis of mediastinal masses and to emphasize the need for specific anaerobic cultures to improve the diagnostic yield.
放线菌病是一种罕见的慢性肉芽肿性传染病。它们是人体各个部位的共生菌,但致病性很低。放线菌是最常见的菌种,但已描述的菌种超过30种。下呼吸道感染并不常见,纵隔受累更为罕见。
一名63岁男性,既往健康,居住在农村地区,出现咯血、胸膜炎性疼痛、体重减轻和盗汗5个月。记录为社区获得性肺炎伴纵隔肿块,为此他接受了抗生素治疗。由于经皮活检结果不明确,进行了胸腔镜检查以诊断和切除纵隔肿块。病理报告在格罗科特染色中可见丝状革兰氏阳性菌。由于病理结果以及未发现其他感染病原体,确诊为放线菌病。开始口服阿莫西林1g,每日三次,治疗6个月。
据我们所知,我们报告的是第六例纵隔放线菌病。我们报告此病例是为了引起对这种罕见但临床上相关表现的关注,将其作为纵隔肿块的鉴别诊断加以考虑,并强调需要进行特定的厌氧菌培养以提高诊断率。