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医疗服务提供者对纳洛酮的态度与阿片类药物使用障碍患者及其自我报告的“低门槛”治疗实践之间的关联。

The association of medical providers' attitudes about naloxone and people with opioid use disorder and their self-reported "low-barrier" treatment practices.

作者信息

Winograd Rachel P, Coffey Bridget, Nance Melissa, Carpenter Ryan

机构信息

University of Missouri-St. Louis, USA.

出版信息

Addict Behav Rep. 2023 Aug 26;18:100514. doi: 10.1016/j.abrep.2023.100514. eCollection 2023 Dec.

Abstract

Opioid-involved overdose deaths continue to climb, in part because of suboptimal access to and retention on medications for opioid use disorder (MOUD), including buprenorphine. Low barrier buprenorphine treatment aims to reduce or eliminate the threshold for getting and staying on medication by providing immediate and long-term access to buprenorphine without strict rules or requirements. This study examines associations between medical providers' beliefs about treating people with opioid use disorder (OUD) and naloxone access with their self-reported low-barrier buprenorphine prescribing practices. We surveyed and analyzed responses from providers (N = 86) who completed X-waiver courses in Missouri between March 2017 and September 2019, of which 55% ( = 47) both completed the full survey and endorsed prescribing buprenorphine since the training. The survey included questions about buprenorphine prescribing behaviors as well as the Naloxone-Related Risk Compensation Beliefs (NaRCC-B) scale and the Attitudes toward Patients with OUD scale. Analyses consisted of a series of linear and logistic regressions with the NaRCC-B and OUD Attitudes scales predicting various domains of low-barrier prescribing behaviors. Findings indicate medical providers' beliefs about treating people with OUD are associated with their practice of addiction medicine, with individuals with more favorable views being more likely to endorse low-barrier buprenorphine prescribing practices including offering telemedicine and at-home inductions, prescribing higher doses of buprenorphine, treating larger caseloads, and discussing overdose risk and protective factors with their patients. Providers' beliefs about naloxone being enabling were less related to their buprenorphine practices but strongly related to their likelihood of providing naloxone. Future research may examine which strategies effectively change prescriber attitudes and their adoption of lower-barrier prescribing practices.

摘要

涉及阿片类药物的过量死亡人数持续攀升,部分原因是获得和持续使用阿片类药物使用障碍(MOUD)药物(包括丁丙诺啡)的情况不理想。低门槛丁丙诺啡治疗旨在通过提供即时和长期的丁丙诺啡获取途径,且无需严格规则或要求,来降低或消除获取和持续使用药物的门槛。本研究探讨了医疗服务提供者对治疗阿片类药物使用障碍(OUD)患者的信念以及纳洛酮获取情况与他们自我报告的低门槛丁丙诺啡处方行为之间的关联。我们对2017年3月至2019年9月期间在密苏里州完成X豁免课程的提供者(N = 86)进行了调查并分析了他们的回复,其中55%(n = 47)既完成了完整调查,又认可自培训以来开具丁丙诺啡的处方。该调查包括有关丁丙诺啡处方行为的问题,以及纳洛酮相关风险补偿信念(NaRCC - B)量表和对OUD患者态度量表。分析包括一系列线性和逻辑回归,使用NaRCC - B量表和OUD态度量表预测低门槛处方行为的各个领域。研究结果表明,医疗服务提供者对治疗OUD患者的信念与他们的成瘾医学实践相关,持更积极观点的个体更有可能认可低门槛丁丙诺啡处方行为,包括提供远程医疗和在家诱导、开具更高剂量的丁丙诺啡、治疗更多病例以及与患者讨论过量风险和保护因素。提供者对纳洛酮具有促成作用的信念与他们的丁丙诺啡实践相关性较小,但与他们提供纳洛酮的可能性密切相关。未来的研究可以探讨哪些策略能有效改变开处方者的态度以及他们采用低门槛处方行为的情况。

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本文引用的文献

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Defining Low-threshold Buprenorphine Treatment.定义低门槛丁丙诺啡治疗。
J Addict Med. 2020 Mar/Apr;14(2):95-98. doi: 10.1097/ADM.0000000000000555.

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