全球嗜铬细胞瘤的趋势和现状：对过去 20 年文献发表情况的计量分析。

OBJECTIVE: Pheochromocytoma is a rare catecholamine-producing neuroendocrine tumour originating from the chromaffin cells of the adrenal medulla or extra-adrenal paraganglia. However, there are few bibliometric studies on Pheochromocytoma. Therefore, this study was employed to summarize the global trends and current status in pheochromocytoma by bibliometric analysis. MATERIALS AND METHODS: The Web of Science (WOS) core collection database was searched for publications relating to pheochromocytoma from 2001 to 2021. Bibliometric analysis was used to examine the data, and Microsoft Excel was utilized to create bar graphs. In addition, VOSviewer was used to carry out co-authorship analysis, co-citation analysis and co-occurrence analysis. CiteSpace was used to analyze the keywords citation bursts. RESULTS: A total of 8,653 publications published in 1,806 journals by 38,590 authors in 6,117 organizations from 100 countries/regions were included in our study. Among them, USA was the leading countries in terms of total publications and sum of time cited, whereas Eunice Kennedy Shriver Natl Inst Child Hlth & Hum was the leading institutions. The main publications for pheochromocytoma-related articles were . Pacak karel and Eisenhofer Graeme were the main contributing authors. The studies on pheochromocytoma could be grouped into five clusters: Treatment, Mechanism, Etiology, Radiology and Hormones study. Moreover, the radiology study, etiology study and some specific keywords such germlines mutation, mesenchymal stem-cells, autophagy, neuroinflammation, neurotoxicity, and hemodynamic instability, may become the hot spots of future. CONCLUSION: Although the number of articles on pheochromocytoma has fluctuated slightly over the past 20 years, there has been an overall upward trend. In general, precision medicine research on pheochromocytoma, especially metastatic pheochromocytoma, in terms of diagnosis, treatment, and etiology will be a hot research topic in the future. This study helps to understand the research perspectives, hot spots and trends of pheochromocytoma and provide new insight and a basis for future pheochromocytoma research quickly.

目的：嗜铬细胞瘤是一种罕见的儿茶酚胺分泌性神经内分泌肿瘤，起源于肾上腺髓质或肾上腺外副神经节的嗜铬细胞。然而，关于嗜铬细胞瘤的文献计量研究较少。因此，本研究通过文献计量分析总结全球嗜铬细胞瘤的趋势和现状。

材料和方法：在 Web of Science (WOS) 核心合集数据库中，检索了 2001 年至 2021 年与嗜铬细胞瘤相关的出版物。使用文献计量分析方法对数据进行分析，使用 Microsoft Excel 创建柱状图。此外，还使用 VOSviewer 进行了共著分析、共被引分析和共词分析。使用 CiteSpace 分析关键词的引文突现。

结果：本研究共纳入 100 个国家/地区的 6117 个组织的 38590 名作者在 1806 种期刊上发表的 8653 篇出版物。其中，美国在总出版物和被引时间总和方面处于领先地位，而 Eunice Kennedy Shriver Natl Inst Child Hlth & Hum 则是领先的机构。与嗜铬细胞瘤相关文章的主要出版物是. Pacak karel 和 Eisenhofer Graeme 是主要的贡献作者。嗜铬细胞瘤的研究可以分为五个聚类：治疗、机制、病因、放射学和激素研究。此外，放射学研究、病因学研究以及某些特定关键词，如胚系突变、间充质干细胞、自噬、神经炎症、神经毒性和血液动力学不稳定，可能成为未来的热点。

结论：尽管过去 20 年来，关于嗜铬细胞瘤的文章数量略有波动，但总体呈上升趋势。总的来说，针对嗜铬细胞瘤，特别是转移性嗜铬细胞瘤的精准医学研究，在诊断、治疗和病因方面将是未来的一个热门研究课题。本研究有助于了解嗜铬细胞瘤的研究视角、热点和趋势，并为未来的嗜铬细胞瘤研究提供新的见解和基础。