UNLABELLED: This study attempted to draw the present and future perspective of the COVID-19 vaccine by identifying the most important scientists and their scientific contexts, trends of research topics, and relationships between different entities. METHODS: To achieve this purpose, bibliometric and scientometric techniques were used to analyze 6288 scientific documents contributing to COVID-19 vaccines from the beginning of 2019 to 13 December 2021, indexed in the Web of Science. RESULTS: The United States (US) had the greatest impact by publishing 2104 documents and receiving 32,958 citations. The US and the UK countries had the highest level of scientific collaborations with 192 collaborative studies. The University of Oxford and the Harvard Medical School were the most active institutions, and the University of Oxford and Emory University were the most influential institutions. Pollard AJ and Lambe T had the most publications and the highest citations and h-index. T Lambe, SC Gilbert, M Voysey, and AJ Pollard from the University of Oxford had the highest number of co-authorships. More than 19% of the research was conducted in the field of immunology. journal had the most publications, with 425 articles. The US Department of Health & Human Services granted the most research. In 2019, studies were focused on the topics of COVID-19 virus identification and ways to deal with it; in 2020, studies focused on the topics of COVID-19 and vaccines, whereas in 2021, they focused on the topics of COVID-19 vaccines and their effects, vaccines hesitancy, the role of healthcare workers in COVID-19, as well as discussions about these vaccines in the social media. CONCLUSIONS: Recognition of the most important actors (countries, institutes, researchers, and channels for the release of COVID-19 vaccine studies), research trends, and fields of study on the COVID-19 vaccine can be useful for researchers, countries, and policy makers in the field of science and health to make decisions and better understand these vaccines.