Alshammari Mohammed K, Alsanad Ahlam H, Alnusayri Rawan J, Alanazi Abdulmajeed S, Shamakhi Fatmah Q, Alshahrani Khaled M, Alshahrani Abdullah M, Yahya Ghaliah, Alshahrani Abdulaziz A, Alshahrani Turki S, Sultan Hamad S, Alshahrani Fatimah M, Alreshidi Fouzyia A, Alnigaidan Renad A, Almazyad Abdulaziz A
Department of Clinical Pharmacy, King Fahad Medical City Hospital, Riyadh, Saudi Arabia.
Department of Neonatal Intensive Care Unit, Maternity and Children Hospital, Dammam, Saudi Arabia.
Front Pediatr. 2023 Aug 23;11:1206389. doi: 10.3389/fped.2023.1206389. eCollection 2023.
Neonatal early onset sepsis (NEOS) is a serious and potentially life-threatening condition affecting newborns within the first few days of life. While the diagnosis of NEOS was based on clinical signs and symptoms in the past, recent years have seen growing interest in identifying specific diagnostic factors and optimizing therapy outcomes. This study aims to investigate the diagnostic and risk factors and therapy outcomes of neonatal EOS in ICU patients in Saudi Arabia, with the goal of improving the management of neonatal EOS in the country.
This method outlines the protocol development, search strategy, study selection, and data collection process for a systematic review on neonatal early onset sepsis in Saudi Arabian ICU patients, following the PRISMA 2020 guidelines. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) is a well-established guideline that provides a framework for conducting systematic reviews and meta-analyses in a transparent and standardized manner. It aims to improve the quality and reporting of such research by ensuring clear and comprehensive reporting of study methods, results, and interpretations. The search strategy included electronic databases (PubMed, Embase, Google Scholar, Science Direct, and the Cochrane Library) and manual search of relevant studies, and data were extracted using a standardized form.
The systematic review included 21 studies on neonatal sepsis in Saudi Arabia, with varying study designs, sample sizes, and prevalence rates of sepsis. Group B streptococcus and E. coli were the most commonly isolated pathogens. Various diagnostic factors and risk factors were reported, including hematological parameters, biomarkers, and blood cultures. The quality of the included studies was assessed using the Newcastle-Ottawa Scale and Joanna Briggs Institute critical checklist.
The review identified a number of risk and diagnostic factors and therapy outcomes for neonatal sepsis. However, most of the studies were having small scale cohort groups. Further research with controlled study designs is needed to develop effective prevention and management strategies for neonatal sepsis in Saudi Arabia.
新生儿早发型败血症（NEOS）是一种严重且可能危及生命的疾病，影响出生后几天内的新生儿。过去，NEOS的诊断基于临床体征和症状，但近年来，人们越来越关注识别特定的诊断因素并优化治疗结果。本研究旨在调查沙特阿拉伯重症监护病房（ICU）患者中新生儿早发型败血症的诊断、危险因素及治疗结果，目标是改善该国新生儿早发型败血症的管理。
本方法概述了对沙特阿拉伯ICU患者新生儿早发型败血症进行系统评价的方案制定、检索策略、研究选择和数据收集过程，遵循PRISMA 2020指南。PRISMA（系统评价和Meta分析的首选报告项目）是一个成熟的指南，它提供了一个以透明和标准化方式进行系统评价和Meta分析的框架。其目的是通过确保清晰全面地报告研究方法、结果和解释来提高此类研究的质量和报告水平。检索策略包括电子数据库（PubMed、Embase、谷歌学术、Science Direct和Cochrane图书馆）以及对相关研究的手动检索，并使用标准化表格提取数据。
该系统评价纳入了21项关于沙特阿拉伯新生儿败血症的研究，研究设计、样本量和败血症患病率各不相同。B族链球菌和大肠杆菌是最常见的分离病原体。报告了各种诊断因素和危险因素，包括血液学参数、生物标志物和血培养。使用纽卡斯尔-渥太华量表和乔安娜·布里格斯研究所关键检查表评估纳入研究的质量。
该评价确定了新生儿败血症的一些危险因素、诊断因素及治疗结果。然而，大多数研究的队列组规模较小。需要进一步开展对照研究设计的研究，以制定沙特阿拉伯新生儿败血症的有效预防和管理策略。
