Department of Health Science and Technology, Gachon Advanced Institute for Health Sciences & Technology, Gachon University, Incheon 21999, Republic of Korea.
Neuroscience Research Institute, Gachon University, Incheon 21565, Republic of Korea.
Cells. 2023 Aug 23;12(17):2133. doi: 10.3390/cells12172133.
Stroke is a major global health problem that causes significant mortality and long-term disability. Post-stroke neurological impairment is a complication that is often underestimated with the risk of persistent neurological deficits. Although traditional Chinese medicines have a long history of being used for stroke, their scientific efficacy remains unclear. , an herbal component known for its anti-inflammatory and antioxidant properties, has traditionally been used to treat brain disorders. This study investigated the therapeutic effects of the extraction (SB) during the acute stage of ischemic stroke using photothrombotic (PTB)-induced and transient middle cerebral artery occlusion (tMCAO) model mice. We found that SB mitigated ischemic brain injury, as evidenced by a significant reduction in the modified neurological severity score in the acute stage of PTB and both the acute and chronic stages of tMCAO. Furthermore, we elucidated the regulatory role of SB in the necroptosis and pyroptosis pathways during the acute stage of stroke, underscoring its protective effects. Behavioral assessments demonstrated the effectiveness of SB in ameliorating motor dysfunction and cognitive impairment compared to the group receiving the vehicle. Our findings highlight the potential of SB as a promising therapeutic candidate for stroke. SB was found to help modulate the programmed cell death pathways, promote neuroprotection, and facilitate functional recovery.
中风是一个全球性的主要健康问题，会导致高死亡率和长期残疾。中风后的神经功能损伤是一种经常被低估的并发症，存在持续神经功能缺陷的风险。虽然中药在治疗中风方面有悠久的历史，但它们的科学疗效仍不清楚。丹参酮，一种具有抗炎和抗氧化特性的草药成分，传统上被用于治疗脑部疾病。本研究使用光血栓形成（PTB）诱导和短暂性大脑中动脉闭塞（tMCAO）模型小鼠，探讨了丹参酮提取物（SB）在缺血性中风急性期的治疗效果。我们发现 SB 减轻了缺血性脑损伤，这表现在 PTB 急性阶段和 tMCAO 急性和慢性阶段的改良神经严重程度评分显著降低。此外，我们阐明了 SB 在中风急性期对坏死性凋亡和焦亡途径的调节作用，突出了其保护作用。行为评估表明，与接受载体的组相比，SB 在改善运动功能障碍和认知障碍方面具有更好的效果。我们的研究结果强调了 SB 作为中风有前途的治疗候选药物的潜力。SB 被发现有助于调节程序性细胞死亡途径，促进神经保护，并促进功能恢复。
