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携带利福平耐药相关突变 H445Y 会通过 I 型干扰素抑制免疫。

carrying the rifampicin drug-resistance-conferring mutation H445Y is associated with suppressed immunity through type I interferons.

机构信息

Department of Molecular Microbiology, Washington University School of Medicine , St. Louis, Missouri, USA.

Department of Microbiology, University of Chicago , Chicago, Illinois, USA.

出版信息

mBio. 2023 Oct 31;14(5):e0094623. doi: 10.1128/mbio.00946-23. Epub 2023 Sep 8.

DOI:10.1128/mbio.00946-23
PMID:37682004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10653897/
Abstract

This study highlights the impact of specific rifampicin-resistance-conferring mutations on the host immune response to (), the causative agent of tuberculosis (TB). Clinical reports have previously suggested that multi-drug-resistant) TB patients exhibit altered peripheral immune responses as compared with their drug-sensitive TB counterparts. The murine model of infection with strains carrying drug-resistance-conferring mutations recapitulated these findings and allowed us to mechanistically interrogate the pathways responsible for driving the divergent immune responses. Our findings underscore the need for greater investigation into bacterial heterogeneity to better appreciate the diversity in host-pathogen interactions during TB disease.

摘要

本研究强调了特定利福平耐药相关突变对宿主对结核分枝杆菌（TB）反应的影响。临床报告先前表明，与敏感型药物相比，耐多药结核分枝杆菌患者的外周免疫反应发生改变。携带耐药相关突变的结核分枝杆菌菌株感染的小鼠模型再现了这些发现，并使我们能够从机制上探讨导致不同免疫反应的途径。我们的研究结果强调需要进一步研究细菌异质性，以更好地了解结核病期间宿主-病原体相互作用的多样性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf33/10653897/51462ea77724/mbio.00946-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf33/10653897/b92cd4222c05/mbio.00946-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf33/10653897/9aeb32283c37/mbio.00946-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf33/10653897/9b4b2c9097bc/mbio.00946-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf33/10653897/2d6d2fef0e57/mbio.00946-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf33/10653897/51462ea77724/mbio.00946-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf33/10653897/b92cd4222c05/mbio.00946-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf33/10653897/9aeb32283c37/mbio.00946-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf33/10653897/9b4b2c9097bc/mbio.00946-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf33/10653897/2d6d2fef0e57/mbio.00946-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf33/10653897/51462ea77724/mbio.00946-23.f005.jpg

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