The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China.
Medicine (Baltimore). 2023 Sep 8;102(36):e35013. doi: 10.1097/MD.0000000000035013.
The aim of this paper was to reveal the correlation between the expression of ELOVL fatty acid elongase 6 (ELOVL6) gene in lung adenocarcinoma (LUAD) and its clinical significance, immune cell infiltration level and prognosis. Expression profile data of ELOVL6 mRNA were collected from the cancer genome atlas database to analyze the differences in ELOVL6 mRNA expression in LUAD tissues and normal lung tissues, and to analyze the correlation between ELOVL6 and information on clinicopathological features. Based on TIMER database, TISDIB database and GEPIA2 database, the correlation between ELOVL6 expression and tumor immune cell infiltration in LUAD was analyzed. Gene ontology and Kyoto encyclopedia of genes and genomes enrichment analyses of ELOVL6-related co-expressed genes were performed to identify the involved signaling pathways and to construct their co-expressed gene protein interaction networks. Drugs affected by ELOVL6 expression were screened based on the Cell Miner database. These findings suggest that ELOVL6 plays an important role in the course of LUAD, and the expression level of this gene has a close relationship with clinicopathological characteristics and survival prognosis, and has the potential to become a prognostic marker and therapeutic target for LUAD.
本文旨在揭示肺腺癌（LUAD）中 ELOVL 脂肪酸延长酶 6（ELOVL6）基因的表达与其临床意义、免疫细胞浸润水平和预后之间的相关性。从癌症基因组图谱数据库中收集 ELOVL6 mRNA 的表达谱数据，以分析 LUAD 组织和正常肺组织中 ELOVL6 mRNA 表达的差异，并分析 ELOVL6 与临床病理特征信息之间的相关性。基于 TIMER 数据库、TISDIB 数据库和 GEPIA2 数据库，分析 ELOVL6 表达与 LUAD 肿瘤免疫细胞浸润的相关性。对 ELOVL6 相关共表达基因进行基因本体和京都基因与基因组百科全书富集分析，以确定涉及的信号通路，并构建其共表达基因蛋白相互作用网络。基于 Cell Miner 数据库筛选受 ELOVL6 表达影响的药物。这些发现表明，ELOVL6 在 LUAD 的发生发展过程中起着重要作用，该基因的表达水平与临床病理特征和生存预后密切相关，有望成为 LUAD 的预后标志物和治疗靶点。
