Department of The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Foshan, China.
Department of Neurology, General Hospital of Northern Theater Command, Shenyang, China.
Medicine (Baltimore). 2023 Sep 8;102(36):e34982. doi: 10.1097/MD.0000000000034982.
Alzheimer's disease (AD) is a common cause of dementia and frailty. Therefore, it is important to develop biomarkers that can diagnose these changes to improve the likelihood of monitoring and treating potential causes. Therefore, this study aimed to examine the relationship between biomarkers and AD, identify journal publications and collaborators, and analyze keywords and research trends using a bibliometric method.
We systematically searched for papers published in the Web of Science Core Collection database on biomarkers and AD. The search strategy was as follows: (TS) = (Alzheimer's OR Alzheimer's OR Alzheimer OR "Alzheimer's disease" OR "Alzheimer disease") AND TS = (biomarker OR biomarkers). Only articles and reviews were included as document types, with English as the primary language. The CiteSpace software was used to analyze the retrieved data on countries/regions, institutions, authors, published journals, and keywords. Simultaneously, the co-occurrence of the keywords was constructed.
There were 2625 articles on biomarkers and AD research published by 51 institutions located in 41 countries in 75 journals; the number of articles has shown an increasing trend over the past 20 years. Keywords analysis showed that Alzheimer's disease, cerebrospinal fluid, mild cognitive impairment, amyloid beta, and tau were also highly influential.
This was the first study to provide an overview of the current status of development, hot spots of study, and future trends in biomarkers for AD. These findings will provide useful information for researchers to explore trends and gaps in the field of biomarkers and AD.
阿尔茨海默病（AD）是痴呆和衰弱的常见原因。因此，开发能够诊断这些变化的生物标志物对于提高监测和治疗潜在病因的可能性非常重要。因此，本研究旨在通过文献计量学方法探讨生物标志物与 AD 的关系，确定期刊出版物和合作者，并分析关键词和研究趋势。
我们系统地在 Web of Science 核心合集数据库中搜索了关于生物标志物和 AD 的论文。搜索策略如下：（TS）=（阿尔茨海默氏症 OR 阿尔茨海默氏症 OR 阿尔茨海默氏病 OR “阿尔茨海默病”）AND TS =（生物标志物 OR 生物标志物）。仅将文章和综述作为文档类型，以英语为主要语言。使用 CiteSpace 软件分析从检索数据中提取的国家/地区、机构、作者、出版期刊和关键词。同时，构建了关键词的共现。
在过去的 20 年里，共有来自 41 个国家的 51 家机构在 75 种期刊上发表了 2625 篇关于生物标志物和 AD 研究的文章；文章数量呈上升趋势。关键词分析表明，阿尔茨海默病、脑脊液、轻度认知障碍、淀粉样β和 tau 也是高度有影响力的。
这是第一项关于 AD 生物标志物发展现状、研究热点和未来趋势的综述。这些发现将为研究人员探索生物标志物和 AD 领域的趋势和差距提供有用的信息。
