匹那地尔对人体的急性血流动力学效应。
Acute haemodynamic effects of pinacidil in man.
作者信息
Nicholls D P, Murtagh J G, Scott M E, Morton P, Shanks R G
出版信息
Br J Clin Pharmacol. 1986 Sep;22(3):287-92. doi: 10.1111/j.1365-2125.1986.tb02889.x.
The acute haemodynamic effects of i.v. pinacidil 0.2 mg kg-1 infused over 8 min were studied in 10 normotensive patients undergoing cardiac catheterisation. Mean arterial pressure fell from 94 +/- 3 mmHg (mean +/- s.e. mean) before infusion to 74 +/- 3 mmHg at 10 min after commencing infusion (P less than 0.001) and during this time heart rate increased from 75 +/- 4 to 106 +/- 7 beats min-1 (P less than 0.001). Significant changes were recorded until the end of the observation period (70 min after commencing infusion). Cardiac index increased from 3.2 +/- 0.2 to 4.0 +/- 0.2 l min-1 m-2 (P less than 0.001) and systemic vascular resistance fell from 16 +/- 1 to 10 +/- 1 units (P less than 0.001) at 10 min after commencing infusion. By the end of the observation period, the values had returned to pre-infusion levels. Only small changes in pulmonary haemodynamics were observed. These results indicate that pinacidil acts as a peripheral arteriolar vasodilator, and as such may have a role in the treatment of arterial hypertension and of cardiac failure.
对10名接受心导管插入术的血压正常患者研究了静脉注射吡那地尔0.2mg/kg、历时8分钟的急性血流动力学效应。平均动脉压从注射前的94±3mmHg（均值±标准误均值）降至开始注射后10分钟时的74±3mmHg（P<0.001），在此期间心率从75±4次/分钟增至106±7次/分钟（P<0.001）。直到观察期结束（开始注射后70分钟）都记录到显著变化。开始注射后10分钟时心脏指数从3.2±0.2增至4.0±0.2升/分钟·平方米（P<0.001），全身血管阻力从16±1降至10±1单位（P<0.001）。到观察期结束时，这些数值已恢复至注射前水平。仅观察到肺血流动力学有微小变化。这些结果表明吡那地尔起外周小动脉血管扩张剂的作用，因此可能在动脉高血压和心力衰竭的治疗中发挥作用。
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