Nielsen C B, Pedersen E B
Department of Medicine and Nephrology C, Skejby Hospital University Hospital, Aarhus, Denmark.
Eur J Clin Pharmacol. 1993;45(1):29-35. doi: 10.1007/BF00315346.
The effects of pinacidil on renal haemodynamics, tubular function evaluated by the lithium clearance technique and the plasma levels of angiotensin II (Ang II), aldosterone (Aldo) and atrial natriuretic peptide (ANP) have been evaluated in 12 healthy volunteers given pinacidil 0.1 mg/kg IV in comparison with a placebo given to 13 different healthy volunteers. Pinacidil induced significant reductions in glomerular filtration rate (-5%), renal plasma flow (-12%), urine output (-35%), urinary sodium excretion (-20%), and the fractional excretion of sodium (-17%) and potassium (-29%). Lithium clearance and proximal and distal absolute and fractional reabsorption of sodium were not significantly changed. Ang II and Aldo were significantly increased (80% and 115%, respectively) and ANP was unchanged. The mean arterial blood pressure was not significantly changed by pinacidil, but the heart rate was increased (22%). It is concluded that bolus IV injection of pinacidil in healthy subjects reduced renal blood flow, urine volume and the urinary excretion of sodium and potassium, whereas segmental tubular function was unchanged. The increase in heart rate and activation of the renin-angiotensin-aldosterone system are most likely to be secondary to stimulation of the sympathetic nervous system caused by the vasodilator effect of pinacidil.
在12名健康志愿者静脉注射0.1mg/kg吡那地尔，并与13名不同的健康志愿者注射安慰剂进行对比的实验中，评估了吡那地尔对肾血流动力学、通过锂清除技术评估的肾小管功能以及血管紧张素II（Ang II）、醛固酮（Aldo）和心钠素（ANP）血浆水平的影响。吡那地尔使肾小球滤过率显著降低（-5%）、肾血浆流量显著降低（-12%）、尿量显著降低（-35%）、尿钠排泄显著降低（-20%）以及钠（-17%）和钾（-29%）的分数排泄显著降低。锂清除率以及近端和远端钠的绝对和分数重吸收没有显著变化。Ang II和Aldo显著增加（分别为80%和115%）而ANP没有变化。吡那地尔未使平均动脉血压显著改变，但使心率增加（22%）。得出的结论是，在健康受试者中静脉推注吡那地尔会降低肾血流量、尿量以及钠和钾的尿排泄，而节段性肾小管功能未改变。心率增加和肾素-血管紧张素-醛固酮系统的激活很可能继发于吡那地尔的血管舒张作用对交感神经系统的刺激。
