孕妇体内咖啡因的尿液代谢物。
Urinary metabolites of caffeine in pregnant women.
作者信息
Scott N R, Chakraborty J, Marks V
出版信息
Br J Clin Pharmacol. 1986 Oct;22(4):475-8. doi: 10.1111/j.1365-2125.1986.tb02920.x.
Abstract
In a study of caffeine and its metabolites in pregnant and non-pregnant women, on average 56.8% of the administered caffeine dose was recovered in the urine in both groups. However, compared to the controls, the pregnant subjects produced smaller amounts of 1-methylxanthine and 1-methyluric acid, whereas the excretion of most of the other metabolites, particularly 3,7-dimethylxanthine and 3-methylxanthine tended to be greater. It is suggested that hormonal influences on the hepatic caffeine metabolising enzymes might be implicated.
摘要
在一项针对孕妇和非孕妇体内咖啡因及其代谢物的研究中，两组中平均有56.8%的摄入咖啡因剂量在尿液中被回收。然而，与对照组相比，怀孕受试者产生的1-甲基黄嘌呤和1-甲基尿酸量较少，而其他大多数代谢物的排泄，尤其是3,7-二甲基黄嘌呤和3-甲基黄嘌呤的排泄量往往更大。这表明可能涉及激素对肝脏咖啡因代谢酶的影响。
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