Kaltsas Gregory, Walter Thomas, Knigge Ulrich, Toumpanakis Christos, Santos Ana P, Begum Nehara, Pape Ulrich F, Volante Marco, Frilling Andrea, Couvelard Anne
1st Propaedeutic Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Department of Medical Oncology, Edoard Herriot Hospital, Lyon, France.
J Neuroendocrinol. 2023 Oct;35(10):e13332. doi: 10.1111/jne.13332. Epub 2023 Sep 8.
The aim of the present guidance paper is to update the previous ENETS guidelines on well differentiated appendiceal neuroendocrine tumours (NET), providing practical guidance for the diagnosis and management of appendiceal NET (aNET); poorly differentiated neoplasms are dealt with in a separate guidance paper. This paper is structured on a question-answer format in order to also address controversial issues and areas where uncertainty regarding the management and follow-up of aNET exists. All recommendations are offered on the basis of the best available evidence, along with the authors' experiences in managing these neoplasms. Each recommendation for treatment will provide a level of evidence and grade of recommendation as per the GRADE system (adapted in Infectious Disease Society of United States Public Health Service grading system).
本指导性文件的目的是更新欧洲神经内分泌肿瘤学会（ENETS）先前关于高分化阑尾神经内分泌肿瘤（NET）的指南，为阑尾NET（aNET）的诊断和管理提供实用指导；低分化肿瘤在另一篇指导性文件中论述。本文采用问答形式构建，以解决有争议的问题以及在aNET管理和随访方面存在不确定性的领域。所有建议均基于现有最佳证据，并结合作者在管理这些肿瘤方面的经验。每项治疗建议将根据GRADE系统（采用美国公共卫生服务传染病学会分级系统）提供证据水平和推荐等级。
