AlAli Mohammed N, AlWadani Salman T, Amer Sadiq M, Essa Mohamed S, AlAmodi Maha, AlHassan Hussain M, Alrasheed Arwa F, Alsulaiman Ahlam A, Aldeghaither Saud K
Department of Surgery, Prince Mohammed bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia.
Department of Pathology, Prince Mohammed bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia.
J Surg Case Rep. 2025 Apr 23;2025(4):rjaf237. doi: 10.1093/jscr/rjaf237. eCollection 2025 Apr.
Appendiceal neuroendocrine tumors (ANETs) are rare gastrointestinal malignancies that are often diagnosed incidentally during or after surgery for suspected appendicitis, presenting significant diagnostic challenges. Existing studies primarily focus on the epidemiology and management of ANETs but lack comprehensive analyses of diagnostic limitations and treatment outcomes. This study presents five cases of ANETs, emphasizing the ongoing challenges in preoperative diagnosis. Consistent with the medical literature, tumors smaller than 1 cm were effectively managed with appendectomy, whereas a larger tumor with high-risk features necessitated right hemicolectomy. Preoperative imaging consistently failed to identify the tumors, underscoring its limitations in detecting neoplastic causes of appendicitis. These findings highlight the need for larger-scale studies, the development of advanced imaging techniques-particularly with the integration of artificial intelligence-and standardized follow-up protocols for high-risk cases.
阑尾神经内分泌肿瘤（ANETs）是罕见的胃肠道恶性肿瘤，常在因疑似阑尾炎进行手术期间或术后偶然被诊断出来，这带来了重大的诊断挑战。现有研究主要集中在ANETs的流行病学和管理方面，但缺乏对诊断局限性和治疗结果的全面分析。本研究展示了5例ANETs病例，强调了术前诊断中持续存在的挑战。与医学文献一致，小于1厘米的肿瘤通过阑尾切除术可得到有效治疗，而具有高危特征的较大肿瘤则需要进行右半结肠切除术。术前影像学检查一直未能识别出这些肿瘤，凸显了其在检测阑尾炎肿瘤性病因方面的局限性。这些发现强调了开展大规模研究、开发先进成像技术（特别是整合人工智能）以及针对高危病例制定标准化随访方案的必要性。
