Chesley L C, Cooper D W
Br J Obstet Gynaecol. 1986 Sep;93(9):898-908. doi: 10.1111/j.1471-0528.1986.tb08006.x.
Our report concerns the incidences of pre-eclampsia and eclampsia in 147 sisters, 248 daughters, 74 granddaughters, and 131 daughters-in-law of women who have had eclampsia. The disorder is highly heritable. We have analysed the data in two ways, firstly, as a single gene condition and, secondly, as a multifactorial condition. The observed incidences fit closely with the single gene model with frequency of the putative gene being 0.25. When Falconer's method of estimating heritabilities of discrete characters is used, estimates of 120% (sisters), 88% (daughters), and 105% (granddaughters)--none significantly different from 100%-are obtained. Insofar as possible, our definition of pre-eclampsia corresponds with EPH in the descriptive classification of the Organisation Gestosis and to 'severe pre-eclampsia' in Nelson's classification. The women were delivered in many different hospitals, however, and many records fail to provide all of the essential information.
我们的报告涉及子痫患者的147名姐妹、248名女儿、74名孙女和131名儿媳中先兆子痫和子痫的发病率。该病症具有高度遗传性。我们用两种方式分析了数据，其一，作为单基因病症；其二，作为多因素病症。观察到的发病率与单基因模型非常吻合，假定基因的频率为0.25。当使用Falconer估算离散性状遗传力的方法时，得到的遗传力估计值分别为120%（姐妹）、88%（女儿）和105%（孙女），均与100%无显著差异。我们对先兆子痫的定义尽可能与妊娠中毒症组织描述性分类中的EPH以及尼尔森分类中的“重度先兆子痫”相对应。然而，这些女性在许多不同的医院分娩，许多记录未能提供所有必要信息。
