J Drugs Dermatol. 2023 Sep 1;22(9):881-886. doi: 10.36849/JDD.7210.
To meet the unique needs of aging skin of the neck, a new neck cream that enhances nitric oxide availability has been developed to visibly improve signs of aging and overall quality of skin.
The primary objective of this dual center, open label clinical trial was to assess the efficacy and tolerability of the new neck cream applied twice daily over 12 weeks in aging women with mild-to-moderate lines and wrinkles of the neck (Group 1, N=26). A second group with mild-to-moderate lines and wrinkles and photodamage of the neck and décolleté (Group 2, N=10) applied the neck cream (AM/PM) in combination with a double-conjugated retinoid/alpha hydroxy acid (AHA-Ret; PM) to both the neck and décolleté over 12 weeks.
Group 1 demonstrated significant improvements from baseline in the neck of 21% (P=.007) for wrinkles and lines, 27% (P=.004) for skin texture, and 26% (P=.003) for skin tone at 12 weeks. Significant improvements were also observed at 4 and 8 weeks. In Group 2, significant improvements were observed from baseline in the neck and décolleté areas with a 34% (P=.01) improvement in photodamaged skin in the décolleté area. The neck cream was well tolerated with few mild and transient adverse events.
A new neck cream formulated to enhance nitric oxide availability to the skin when applied alone or in combination with AHA-Ret provided statistically significant improvements from baseline in skin appearance of the neck and décolleté, most notably in lines and wrinkles, skin texture, and skin tone.
Robinson DM, Kaufman J, Giannini A, et al. Evaluation of a neck cream developed to enhance nitric oxide availability in aging skin. J Drugs Dermatol. 2023;22(9):881-886. doi:10.36849/JDD.7210.
为满足颈部衰老皮肤的特殊需求，开发了一种可增强一氧化氮供应的新型颈部霜，以显著改善颈部衰老迹象和整体皮肤质量。
这项双中心、开放性临床试验的主要目的是评估新型颈部霜在 26 名有轻度至中度颈纹和皱纹的衰老女性中每天两次应用 12 周的疗效和耐受性（第 1 组）。第 2 组有轻度至中度颈纹和皱纹以及颈部和颈部光损伤的女性（n=10）在 12 周内将颈部霜（上午/晚上）与双共轭视黄醇/α-羟基酸（AHA-Ret；晚上）联合应用于颈部和颈部，显著改善颈部皱纹和皱纹（P=.007），27%（P=.004）改善皮肤纹理，26%（P=.003）改善肤色。在第 2 组中，还观察到从基线开始，颈部和颈部区域的显著改善，颈部区域光损伤皮肤改善 34%（P=.01）。颈部霜耐受性良好，仅有少数轻微和短暂的不良反应。
一种新型颈部霜，旨在单独使用或与 AHA-Ret 联合使用时增强皮肤的一氧化氮供应，在改善颈部和颈部的皮肤外观方面提供了从基线开始的统计学显著改善，尤其是在皱纹、皮肤纹理和肤色方面。
Robinson DM、Kaufman J、Giannini A 等人。评估一种旨在增强衰老皮肤中一氧化氮供应的颈部霜。J 皮肤病学杂志。2023;22(9):881-886。doi:10.36849/JDD.7210.
