J Drugs Dermatol. 2021 Feb 1;20(2):184-191. doi: 10.36849/JDD.5819.
The neck plays a telling role as an age indicator. Due to its anatomy and function, neck skin ages differently than facial skin and special considerations need to be taken when providing treatment. A randomized, double-blind, regimen-controlled study was conducted to assess the efficacy and tolerability of a novel topical cosmetic cream (NCC) specifically tailored to address the signs of skin aging of the neck and décolletage. Twice daily application of NCC significantly improved skin sagging/laxity of the neck as well as the appearance of fine and coarse lines/wrinkles, crepiness, tactile roughness, overall skin texture, hyperpigmentation, skin tone evenness, and radiance. NCC also significantly improved the appearance of fine and coarse lines/wrinkles, tactile roughness, hyperpigmentation, skin tone evenness, and radiance of the décolletage. Investigator assessments were corroborated by objective cutometer measurements that demonstrated improved skin firmness and elasticity. In vitro analysis in human 3D skin models show that stimulation of neocollagenesis and neoelastogenesis as well as support of cellular proteostasis through proteasome and autophagy activation are potential mechanisms of action for the observed clinical outcomes. J Drugs Dermatol. 2021;20(2):184-191. doi:10.36849/JDD.5819 THIS ARTICLE HAD BEEN MADE AVAILABLE FREE OF CHARGE. PLEASE SCROLL DOWN TO ACCESS THE FULL TEXT OF THIS ARTICLE WITHOUT LOGGING IN. NO PURCHASE NECESSARY. PLEASE CONTACT THE PUBLISHER WITH ANY QUESTIONS.
颈部在年龄指示方面起着重要作用。由于其解剖结构和功能，颈部皮肤的衰老与面部皮肤不同，因此在提供治疗时需要特别考虑。进行了一项随机、双盲、方案对照研究，以评估一种专门针对颈部和颈纹皮肤老化迹象的新型局部美容霜（NCC）的疗效和耐受性。每天两次使用 NCC 可显著改善颈部皮肤松弛/松弛以及细纹和皱纹、粗糙感、整体皮肤纹理、色素沉着、肤色均匀度和光泽度的外观。NCC 还显著改善了颈纹的细纹和皱纹、粗糙感、色素沉着、肤色均匀度和光泽度的外观。研究者评估得到了客观皮肤弹性测量仪测量结果的证实，表明皮肤紧实度和弹性得到了改善。在人体 3D 皮肤模型中的体外分析表明，通过蛋白酶体和自噬激活刺激新胶原蛋白和新弹性蛋白的形成以及支持细胞蛋白质稳态是观察到的临床结果的潜在作用机制。J 皮肤病药物杂志。2021;20(2):184-191. doi:10.36849/JDD.5819 本文已免费提供。请向下滚动以访问本文的全文，而无需登录。无需购买。如有任何疑问，请与出版商联系。
