超越皱纹：肉毒毒素用途的综合评价。
Beyond Wrinkles: A Comprehensive Review of the Uses of Botulinum Toxin.
出版信息
J Drugs Dermatol. 2023 Sep 1;22(9):7243e. doi: 10.36849/JDD.7243e.
BACKGROUND
Botulinum neurotoxin (BoNT) exhibits inhibitory effects on the neuromuscular junction, and its use is well established in cosmetic dermatology. Our review aims to analyze the evidence for its use in the treatment of various dermatological, neurological, gastroenterological, ophthalmological, otorhinolaryngological, dental, urological, gynecological, and cardiovascular disorders.
METHODS
A systematic review of the literature was performed for studies published between 2012 and 2022 that discussed the therapeutic use of BoNT in human participants. A total of 58 studies were selected for inclusion in this review.
RESULTS
We discovered a large range of therapeutic applications of BoNT toxin beyond aesthetic and US Food and Drug Administration (FDA)-approved non-aesthetic uses.
CONCLUSIONS
BoNT is a powerful neurotoxin that has varied FDA-approved indications and has been studied in a wide range of therapeutic applications. Further investigation through higher power studies is needed to assess the potential of BoNT and expand its versatility across other medical specialties. J Drugs Dermatol. 2023;22(9): doi:10.36849/JDD.7243e.
背景
肉毒毒素（BoNT）在神经肌肉接头处表现出抑制作用，其在美容皮肤科的应用已得到充分证实。我们的综述旨在分析其在治疗各种皮肤科、神经科、胃肠病学、眼科、耳鼻喉科、牙科、泌尿科、妇科和心血管疾病中的应用证据。
方法
对 2012 年至 2022 年间发表的讨论 BoNT 在人类参与者中的治疗用途的文献进行了系统综述。共选择了 58 项研究纳入本综述。
结果
我们发现 BoNT 毒素的治疗应用范围非常广泛，超出了美容和美国食品和药物管理局（FDA）批准的非美容用途。
结论
BoNT 是一种强大的神经毒素，具有多种 FDA 批准的适应症，并在广泛的治疗应用中进行了研究。需要通过更高功率的研究进一步探索 BoNT 的潜力，并扩大其在其他医学专业中的多功能性。J 皮肤病药物治疗杂志。2023；22（9）：doi:10.36849/JDD.7243e.
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