Doghish Ahmed S, Ali Mohamed A, Elrebehy Mahmoud A, Mohamed Hend H, Mansour Reda, Ghanem Aml, Hassan Ahmed, Elballal Mohammed S, Elazazy Ola, Elesawy Ahmed E, Abdel Mageed Sherif S, Nassar Yara A, Mohammed Osama A, Abulsoud Ahmed I
Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11231, Egypt.
School of Biotechnology, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
Pathol Res Pract. 2023 Oct;250:154790. doi: 10.1016/j.prp.2023.154790. Epub 2023 Sep 6.
Toxoplasmosis is one of the highly prevalent zoonotic diseases worldwide caused by the parasite Toxoplasma gondii (T. gondii). The infection with T. gondii could pass unidentified in immunocompetent individuals; however, latent cysts remain dormant in their digestive tract, but they could be shed and excreted with feces infesting the environment. However, active toxoplasmosis can create serious consequences, particularly in newborns and infected persons with compromised immunity. These complications include ocular toxoplasmosis, in which most cases cannot be treated. Additionally, it caused many stillbirths and miscarriages. Circulating miRNAs are important regulatory molecules ensuring that the normal physiological role of various organs is harmonious. Upon infection with T. gondii, the tightly regulated miRNA profile is disrupted to favor the parasite's survival and further participate in the disease pathogenesis. Interestingly, this dysregulated profile could be useful in acute and chronic disease discrimination and in providing insights into the pathomechanisms of the disease. Thus, this review sheds light on the various roles of miRNAs in signaling pathways regulation involved in the pathogenesis of T. gondii and provides insights into the application of miRNAs clinically for its diagnosis and prognosis.
弓形虫病是一种由寄生虫刚地弓形虫（T. gondii）引起的在全球范围内高度流行的人畜共患病。刚地弓形虫感染在免疫功能正常的个体中可能未被识别；然而，潜伏囊肿在其消化道中保持休眠状态，但它们可能会脱落并随粪便排出，污染环境。然而，活动性弓形虫病会产生严重后果，尤其是在新生儿和免疫功能受损的感染者中。这些并发症包括眼部弓形虫病，其中大多数病例无法治疗。此外，它还导致许多死产和流产。循环微RNA是重要的调节分子，可确保各个器官的正常生理功能协调一致。感染刚地弓形虫后，受到严格调控的微RNA谱会被破坏，以利于寄生虫存活，并进一步参与疾病的发病机制。有趣的是，这种失调的谱可能有助于区分急性和慢性疾病，并深入了解疾病的发病机制。因此，本综述阐明了微RNA在刚地弓形虫病发病机制中涉及的信号通路调节中的各种作用，并为微RNA在其临床诊断和预后中的应用提供了见解。
