Jelen F, Palecek E
Biophys Chem. 1986 Aug;24(3):285-90. doi: 10.1016/0301-4622(86)85033-5.
It was shown that synthetic polynucleotides containing guanine display in cyclic voltammetry (CV) an anodic peak close to -0.3 V (against a saturated calomel electrode). A condition for the appearance of this peak is the previous polarization of the mercury electrode to sufficiently negative potentials (around -1.8 V). The results of CV measurements with electrode polarization by repeated cycles indicate that in negative potentials there is a reduction of guanine residues and in the anodic process reoxidation of the reduction product to guanine. This chemically reversible process takes place even when a polynucleotide contains adenine and/or cytosine residues in addition to guanine, where reduction leads to the formation of products blocking the electrode surface.
结果表明，含有鸟嘌呤的合成多核苷酸在循环伏安法（CV）中显示出一个接近-0.3 V的阳极峰（相对于饱和甘汞电极）。出现该峰的一个条件是先前将汞电极极化至足够负的电位（约-1.8 V）。通过重复循环进行电极极化的CV测量结果表明，在负电位下鸟嘌呤残基会发生还原，而在阳极过程中还原产物会再氧化为鸟嘌呤。即使多核苷酸除了鸟嘌呤之外还含有腺嘌呤和/或胞嘧啶残基，这种化学可逆过程也会发生，其中还原会导致形成阻塞电极表面的产物。
