Muranov K O, Polianskiĭ N B, Shvedova A A, Kagan V E, Smirnov L D
Biull Eksp Biol Med. 1986 Oct;102(10):432-4.
The effect of six 3-oxypiridine derivatives (at a concentration of 10(-3) and 5 X 10(-3) M) on cyclic nucleotide level in human platelets and platelet aggregation was studied. Five 3-oxypiridine derivatives were shown to depress platelet aggregation, four of them causing the increase in cAMP platelet level. The correlation between antiaggregation activity of 3-oxypiridine derivatives and their ability to rise cyclic nucleotide level in human platelets is discussed.
研究了六种3-氧代吡啶衍生物（浓度为10^(-3)和5×10^(-3) M）对人血小板中环核苷酸水平和血小板聚集的影响。结果表明，五种3-氧代吡啶衍生物可抑制血小板聚集，其中四种可使血小板中cAMP水平升高。本文讨论了3-氧代吡啶衍生物的抗聚集活性与其提高人血小板中环核苷酸水平能力之间的相关性。
