Kagan V E, Polianskiĭ N B, Muranov K O, Shvedova A A, Smirnov L D
Biull Eksp Biol Med. 1984 Apr;97(4):416-8.
The effects of 3-hydroxypyridine (3-HP) derivatives on platelet aggregation and platelet phosphodiesterase (PDE) of cyclic nucleotides (cAMP-dependent) were studied. It was shown that some derivatives of 3-HP inhibit platelet aggregation (the most pronounced effect was exerted by 2-benzyl-3- oxypyridine ). Several derivatives o 3-HP given in a concentration 10(-3) M were discovered to inhibit PDE by 40 to 75%. No correlation was found between the efficacy of 3-HP as antiaggregation agents and PDE inhibitors.
研究了3-羟基吡啶（3-HP）衍生物对血小板聚集以及环核苷酸（依赖cAMP）的血小板磷酸二酯酶（PDE）的影响。结果表明，某些3-HP衍生物可抑制血小板聚集（最显著的作用是由2-苄基-3-氧代吡啶发挥的）。发现几种浓度为10⁻³ M的3-HP衍生物可使PDE抑制40%至75%。未发现3-HP作为抗聚集剂和PDE抑制剂的功效之间存在相关性。
