Radić Josipa, Lovrić Kojundžić Sanja, Gelemanović Andrea, Vučković Marijana, Budimir Mršić Danijela, Šupe Domić Daniela, Novaković Maja Dodig, Radić Mislav
Department of Nephrology and Dialysis, University Hospital of Split, 21000 Split, Croatia.
Department of Internal Medicine, School of Medicine, University of Split, 21000 Split, Croatia.
Diagnostics (Basel). 2023 Aug 26;13(17):2768. doi: 10.3390/diagnostics13172768.
Adropin is a secretory peptide that regulates glucose, lipid, and protein metabolism, which is closely related to obesity, insulin resistance, dyslipidemia, and atherogenesis. The serum adropin level is related to sex and depends upon nutritional preferences. This study aims to determine the association between serum adropin levels and body composition parameters in kidney transplant recipients (KTRs), especially emphasizing sex differences. Our case-control study involved 59 KTRs (28 postmenopausal women and 31 men) who were divided into two groups according to sex, and each group of those KTRs was further divided into higher or lower adropin values than the mean value in each sex group. Univariate regression showed a negative association of adropin levels with most anthropometric and body composition parameters in men's KTRs. Contrary to this, the serum adropin level was negatively associated only with phase angle in postmenopausal female KTRs. Multivariate regression showed that skeletal muscle mass and phase angle were the only negative predictors in women's KTRs, whereas in men, negative predictors were BMI and body water. These findings imply that adropin could have a different impact on metabolic homeostasis in KTRs regarding sex and could be considered a negative predictor of body composition in KTRs.
内脂素是一种调节葡萄糖、脂质和蛋白质代谢的分泌肽，与肥胖、胰岛素抵抗、血脂异常和动脉粥样硬化密切相关。血清内脂素水平与性别有关，并取决于营养偏好。本研究旨在确定肾移植受者（KTR）血清内脂素水平与身体成分参数之间的关联，尤其着重于性别差异。我们的病例对照研究纳入了59名KTR（28名绝经后女性和31名男性），根据性别分为两组，每组KTR再根据内脂素值是否高于或低于各性别组的平均值进一步划分。单因素回归显示，男性KTR中内脂素水平与大多数人体测量和身体成分参数呈负相关。与此相反，绝经后女性KTR中血清内脂素水平仅与相位角呈负相关。多因素回归显示，骨骼肌质量和相位角是女性KTR中仅有的负性预测指标，而在男性中，负性预测指标是体重指数和身体水分。这些发现表明，内脂素可能在性别方面对KTR的代谢稳态有不同影响，并且可被视为KTR身体成分的负性预测指标。
