Lorino A M, Lafuma C, Atlan G, Lorino H, Harf A
Bull Eur Physiopathol Respir. 1986 Jul-Aug;22(4):371-4.
The correlation between lung structure and respiratory function was studied in normal hamsters and hamsters with elastase-induced emphysema. Four physiological parameters related to the elasticity of the respiratory system were determined from the quasi-static deflation pressure-volume curve: the shape constant (K) of the mono-exponential model fitted to the curve, the inflated volume (VI) taken as the volume change from a tracheal pressure of 0 to 30 cmH2O, the total respiratory compliance (C), determined near the relaxation volume and the normalized compliance (C/VI). The lung structure was morphologically described by the mean alveolar linear intercept (Lm) and the internal surface area (ISA). The correlations between these indices showed that 1) the four physiological parameters correlate better with Lm than with ISA, and 2) a simple index such as the normalized compliance allows to predict the severity of emphysema satisfactorily (r = 0.85; p less than 10(-6)).
在正常仓鼠和患有弹性蛋白酶诱导性肺气肿的仓鼠中研究了肺结构与呼吸功能之间的相关性。从准静态放气压力-容积曲线确定了与呼吸系统弹性相关的四个生理参数：拟合该曲线的单指数模型的形状常数（K）、作为气管压力从0到30 cmH₂O时的容积变化的充气容积（VI）、在松弛容积附近测定的总呼吸顺应性（C）以及归一化顺应性（C/VI）。通过平均肺泡线性截距（Lm）和内表面积（ISA）对肺结构进行形态学描述。这些指标之间的相关性表明：1）这四个生理参数与Lm的相关性比与ISA的相关性更好；2）一个简单的指标如归一化顺应性能够令人满意地预测肺气肿的严重程度（r = 0.85；p小于10⁻⁶）。
