Faculty of Pharmacy, Yarmouk University, Irbid 21163, Jordan.
Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, 50139 Florence, Italy.
Int J Mol Sci. 2023 Aug 24;24(17):13160. doi: 10.3390/ijms241713160.
Pain represents an international burden and a major socio-economic public health problem. New findings, detailed in this review, suggest that adenosine plays a significant role in neuropathic and inflammatory pain, by acting on its metabotropic adenosine receptors (AAR, AAR, AAR, AAR). Adenosine receptor ligands have a practical translational potential based on the favorable efficacy and safety profiles that emerged from clinical research on various agonists and antagonists for different pathologies. The present review collects the latest studies on selected adenosine receptor ligands in different pain models. Here, we also covered the many hypothesized pathways and the role of newly synthesized allosteric adenosine receptor modulators. This review aims to present a summary of recent research on adenosine receptors as prospective therapeutic targets for a range of pain-related disorders.
疼痛是一种国际负担，也是一个主要的社会经济公共卫生问题。本综述详细介绍了新的发现，表明腺苷通过作用于代谢型腺苷受体（AAR、AAR、AAR、AAR）在神经病理性疼痛和炎症性疼痛中发挥重要作用。基于各种激动剂和拮抗剂在不同病理情况下的临床研究中表现出的良好疗效和安全性特征，腺苷受体配体具有实际的转化潜力。本综述收集了不同疼痛模型中选定的腺苷受体配体的最新研究。在这里，我们还涵盖了许多假设的途径和新合成的变构腺苷受体调节剂的作用。本综述旨在总结最近关于腺苷受体作为一系列与疼痛相关疾病的潜在治疗靶点的研究。
