慢性疼痛管理中的腺苷代谢型受体 - Suppr

Adenosine Metabotropic Receptors in Chronic Pain Management.

作者信息

Luongo Livio, Guida Francesca, Maione Sabatino, Jacobson Kenneth A, Salvemini Daniela

机构信息

Division of Pharmacology, Department of Experimental Medicine, Università della Campania "L. Vanvitelli", Caserta, Italy.

IRCSS, Neuromed, Pozzilli, Italy.

出版信息

Front Pharmacol. 2021 Apr 16;12:651038. doi: 10.3389/fphar.2021.651038. eCollection 2021.

DOI:10.3389/fphar.2021.651038

PMID:33935761

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8085424/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc78/8085424/7951af055b2c/fphar-12-651038-g001.jpg

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Adenosine Metabotropic Receptors in Chronic Pain Management.慢性疼痛管理中的腺苷代谢型受体

Front Pharmacol. 2021 Apr 16;12:651038. doi: 10.3389/fphar.2021.651038. eCollection 2021.

Profound hypothermia after adenosine kinase inhibition in A1AR-deficient mice suggests a receptor-independent effect of intracellular adenosine.A1AR基因缺陷小鼠中腺苷激酶抑制后出现深度低温，提示细胞内腺苷存在不依赖受体的效应。

Pflugers Arch. 2017 Feb;469(2):339-347. doi: 10.1007/s00424-016-1925-3. Epub 2016 Dec 14.

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states.内源性腺苷A3受体激活可选择性减轻持续性疼痛状态。

Brain. 2015 Jan;138(Pt 1):28-35. doi: 10.1093/brain/awu330. Epub 2014 Nov 19.

Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor.犬肥大细胞腺苷受体：A3受体的克隆与表达以及脱颗粒由A2B受体介导的证据

Mol Pharmacol. 1997 Nov;52(5):846-60. doi: 10.1124/mol.52.5.846.

Molecular basis for subtype-specific desensitization of inhibitory adenosine receptors. Analysis of a chimeric A1-A3 adenosine receptor.抑制性腺苷受体亚型特异性脱敏的分子基础。嵌合A1 - A3腺苷受体的分析。

J Biol Chem. 1996 Jun 21;271(25):15272-8. doi: 10.1074/jbc.271.25.15272.

125I-4-aminobenzyl-5'-N-methylcarboxamidoadenosine, a high affinity radioligand for the rat A3 adenosine receptor.125I - 4 - 氨基苄基 - 5'-N - 甲基羧酰胺腺苷，一种对大鼠A3腺苷受体具有高亲和力的放射性配体。

Mol Pharmacol. 1994 May;45(5):978-82.

Adenosine receptors: protein and gene structure.腺苷受体：蛋白质与基因结构

Arch Int Pharmacodyn Ther. 1995 Jan-Feb;329(1):135-50.

Exploring the Role of N-Substituents in Potent Dual Acting 5'-C-Ethyltetrazolyladenosine Derivatives: Synthesis, Binding, Functional Assays, and Antinociceptive Effects in Mice ∇.探索N-取代基在强效双作用5'-C-乙基四唑基腺苷衍生物中的作用：合成、结合、功能测定及对小鼠的镇痛作用∇

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Targeting Adenosine Receptors: A Potential Pharmacological Avenue for Acute and Chronic Pain.靶向腺苷受体：急性和慢性疼痛的潜在药理学途径。

Int J Mol Sci. 2020 Nov 18;21(22):8710. doi: 10.3390/ijms21228710.

Sustained reversal of central neuropathic pain induced by a single intrathecal injection of adenosine A receptor agonists.单次鞘内注射腺苷 A 受体激动剂可持久逆转中枢神经性疼痛。

Brain Behav Immun. 2018 Mar;69:470-479. doi: 10.1016/j.bbi.2018.01.005. Epub 2018 Jan 31.

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Role of spinal astrocytes through the perisynaptic astrocytic process in pathological pain.脊髓星形胶质细胞通过突触周星形胶质细胞突起在病理性疼痛中的作用。

Mol Brain. 2023 Dec 13;16(1):81. doi: 10.1186/s13041-023-01069-z.

Increased Purinergic Signaling in Human Dental Pulps With Inflammatory Pain is Sex-Dependent.炎症性疼痛的人类牙髓中嘌呤能信号增强存在性别依赖性。

J Pain. 2024 Apr;25(4):1039-1058. doi: 10.1016/j.jpain.2023.10.026. Epub 2023 Nov 11.

3', 4'-dihydroxyflavone ameliorates paclitaxel model of peripheral neuropathy in mice by modulating K channel, adenosine (A) and GABA (α subunit) receptors.3',4'-二羟基黄酮通过调节钾通道、腺苷（A）和GABA（α亚基）受体改善小鼠紫杉醇诱导的周围神经病变模型。

Bioinformation. 2023 Jun 30;19(6):754-763. doi: 10.6026/97320630019754. eCollection 2023.

First Potent Macrocyclic A Adenosine Receptor Agonists Reveal G-Protein and β-Arrestin2 Signaling Preferences.首个强效大环A腺苷受体激动剂揭示了G蛋白和β-抑制蛋白2的信号偏好。

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Adenosine Receptors as Potential Therapeutic Analgesic Targets.腺苷受体作为潜在的治疗性镇痛靶点。

Int J Mol Sci. 2023 Aug 24;24(17):13160. doi: 10.3390/ijms241713160.

A1 Adenosine Receptor Activation Inhibits P2X3 Receptor-Mediated ATP Currents in Rat Dorsal Root Ganglion Neurons.A1 腺苷受体激活抑制大鼠背根神经节神经元 P2X3 受体介导的 ATP 电流。

Mol Neurobiol. 2022 Nov;59(11):7025-7035. doi: 10.1007/s12035-022-03019-7. Epub 2022 Sep 8.

Adenosine Targeting as a New Strategy to Decrease Glioblastoma Aggressiveness.靶向腺苷作为降低胶质母细胞瘤侵袭性的新策略。

Cancers (Basel). 2022 Aug 20;14(16):4032. doi: 10.3390/cancers14164032.

Low-dose interleukin-2 reverses chronic migraine-related sensitizations through peripheral interleukin-10 and transforming growth factor beta-1 signaling.低剂量白细胞介素-2通过外周白细胞介素-10和转化生长因子β-1信号通路逆转慢性偏头痛相关的致敏作用。

Neurobiol Pain. 2022 Jun 13;12:100096. doi: 10.1016/j.ynpai.2022.100096. eCollection 2022 Aug-Dec.

Mechanisms of ATP release in pain: role of pannexin and connexin channels.疼痛中 ATP 释放的机制：pannexin 和 connexin 通道的作用。

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Targeting Adenosine Receptors: A Potential Pharmacological Avenue for Acute and Chronic Pain.靶向腺苷受体：急性和慢性疼痛的潜在药理学途径。

Int J Mol Sci. 2020 Nov 18;21(22):8710. doi: 10.3390/ijms21228710.

Chronic Morphine-Induced Changes in Signaling at the A Adenosine Receptor Contribute to Morphine-Induced Hyperalgesia, Tolerance, and Withdrawal.慢性吗啡诱导的 A 腺苷受体信号改变导致吗啡诱导的痛觉过敏、耐受和戒断。

J Pharmacol Exp Ther. 2020 Aug;374(2):331-341. doi: 10.1124/jpet.120.000004. Epub 2020 May 20.

Acute visceral pain relief mediated by A3AR agonists in rats: involvement of N-type voltage-gated calcium channels.A3AR 激动剂介导的大鼠内脏急性疼痛缓解：涉及 N 型电压门控钙通道。

Pain. 2020 Sep 1;161(9):2179-2190. doi: 10.1097/j.pain.0000000000001905.

Treatment of chronic neuropathic pain: purine receptor modulation.慢性神经性疼痛的治疗：嘌呤受体调节

Pain. 2020 Jul;161(7):1425-1441. doi: 10.1097/j.pain.0000000000001857.

Sexually dimorphic therapeutic response in bortezomib-induced neuropathic pain reveals altered pain physiology in female rodents.硼替佐米诱导的神经病理性疼痛中存在性别二态性治疗反应，这表明雌性啮齿动物的疼痛生理学发生了改变。

Pain. 2020 Jan;161(1):177-184. doi: 10.1097/j.pain.0000000000001697.

Adenosine A3 receptor activation inhibits pronociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons.腺苷 A3 受体的激活抑制背根神经节神经元中的伤害性 N 型 Ca2+ 电流和细胞兴奋性。

Pain. 2019 May;160(5):1103-1118. doi: 10.1097/j.pain.0000000000001488.

Targeting the A adenosine receptor to treat cytokine release syndrome in cancer immunotherapy.靶向 A 型腺苷受体治疗癌症免疫疗法中的细胞因子释放综合征。

Drug Des Devel Ther. 2019 Jan 30;13:491-497. doi: 10.2147/DDDT.S195294. eCollection 2019.

A adenosine receptor agonist attenuates neuropathic pain by suppressing activation of microglia and convergence of nociceptive inputs in the spinal dorsal horn.A 型腺苷受体激动剂通过抑制小胶质细胞的激活以及脊髓背角伤害性传入的汇聚来减轻神经性疼痛。

Exp Brain Res. 2018 Dec;236(12):3203-3213. doi: 10.1007/s00221-018-5377-1. Epub 2018 Sep 11.

Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models.阿米替林通过激活大鼠神经病理性疼痛模型中的 A3AR 抑制 MAPK/ERK 和 CREB 通路及促炎细胞因子。

Korean J Anesthesiol. 2019 Feb;72(1):60-67. doi: 10.4097/kja.d.18.00022. Epub 2018 Jul 4.

Downregulation of adenosine and adenosine A1 receptor contributes to neuropathic pain in resiniferatoxin neuropathy.下调腺嘌呤核苷和腺嘌呤 A1 受体有助于树脂毒素神经病变中的神经病理性疼痛。

Pain. 2018 Aug;159(8):1580-1591. doi: 10.1097/j.pain.0000000000001246.

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Adenosine Metabotropic Receptors in Chronic Pain Management.

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