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Adenosine Metabotropic Receptors in Chronic Pain Management.

作者信息

Luongo Livio, Guida Francesca, Maione Sabatino, Jacobson Kenneth A, Salvemini Daniela

机构信息

Division of Pharmacology, Department of Experimental Medicine, Università della Campania "L. Vanvitelli", Caserta, Italy.

IRCSS, Neuromed, Pozzilli, Italy.

出版信息

Front Pharmacol. 2021 Apr 16;12:651038. doi: 10.3389/fphar.2021.651038. eCollection 2021.

DOI:10.3389/fphar.2021.651038
PMID:33935761
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8085424/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc78/8085424/7951af055b2c/fphar-12-651038-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc78/8085424/7951af055b2c/fphar-12-651038-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc78/8085424/7951af055b2c/fphar-12-651038-g001.jpg

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2
Chronic Morphine-Induced Changes in Signaling at the A Adenosine Receptor Contribute to Morphine-Induced Hyperalgesia, Tolerance, and Withdrawal.慢性吗啡诱导的 A 腺苷受体信号改变导致吗啡诱导的痛觉过敏、耐受和戒断。
J Pharmacol Exp Ther. 2020 Aug;374(2):331-341. doi: 10.1124/jpet.120.000004. Epub 2020 May 20.
3
Acute visceral pain relief mediated by A3AR agonists in rats: involvement of N-type voltage-gated calcium channels.
炎症性疼痛的人类牙髓中嘌呤能信号增强存在性别依赖性。
J Pain. 2024 Apr;25(4):1039-1058. doi: 10.1016/j.jpain.2023.10.026. Epub 2023 Nov 11.
4
3', 4'-dihydroxyflavone ameliorates paclitaxel model of peripheral neuropathy in mice by modulating K channel, adenosine (A) and GABA (α subunit) receptors.3',4'-二羟基黄酮通过调节钾通道、腺苷（A）和GABA（α亚基）受体改善小鼠紫杉醇诱导的周围神经病变模型。
Bioinformation. 2023 Jun 30;19(6):754-763. doi: 10.6026/97320630019754. eCollection 2023.
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First Potent Macrocyclic A Adenosine Receptor Agonists Reveal G-Protein and β-Arrestin2 Signaling Preferences.首个强效大环A腺苷受体激动剂揭示了G蛋白和β-抑制蛋白2的信号偏好。
ACS Pharmacol Transl Sci. 2023 Aug 8;6(9):1288-1305. doi: 10.1021/acsptsci.3c00126. eCollection 2023 Sep 8.
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