Research Institute in Healthcare Science, University of Wolverhampton, Wolverhampton WV1 1LY, UK.
Gastroenterology, The Royal Wolverhampton NHS Trust, Wolverhampton WV10 0QP, UK.
Int J Mol Sci. 2023 Aug 28;24(17):13323. doi: 10.3390/ijms241713323.
Following a diagnosis of iron deficiency anaemia in pregnancy, iron supplements are prescribed using UK guidelines; however, despite this, the condition remains highly prevalent, affecting up to 30% of pregnant women in the UK. According to the World Health Organisation, it globally accounts for 45% in the most vulnerable groups of pregnant women and infants (<5 years old). Recently, the efficacy of iron replacement therapy and the effectiveness of current standard testing of iron parameters have been reviewed in order to evaluate whether a more accurate diagnosis can be made using alternative and/or supplementary markers. Furthermore, many questions remain about the mechanisms involved in iron metabolism during pregnancy. The most recent studies have shed more light on serum hepcidin and raised questions on the significance of pregnancy related inflammatory markers including cytokines in iron deficiency anaemia. However, research into this is still scarce, and this review aims to contribute to further understanding and elucidating these areas.
在诊断出孕妇缺铁性贫血后，根据英国的指南规定了补铁治疗；然而，尽管如此，这种情况仍然非常普遍，英国高达 30%的孕妇都受到影响。根据世界卫生组织的数据，在最脆弱的孕妇和婴儿群体（<5 岁）中，缺铁性贫血的全球患病率高达 45%。最近，人们对铁替代治疗的疗效和当前铁参数检测标准的有效性进行了回顾，以评估是否可以使用替代和/或补充标志物进行更准确的诊断。此外，在孕妇铁代谢的相关机制方面仍然存在许多问题。最近的研究进一步揭示了血清铁调素的作用，并提出了关于与妊娠相关的炎症标志物（包括细胞因子）在缺铁性贫血中的意义的问题。然而，对这方面的研究仍然很少，本综述旨在为进一步了解和阐明这些领域做出贡献。
