Department of Orthopedic Surgery and Shanghai Institute of Microsurgery on Extremities, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Front Immunol. 2022 Mar 23;13:816282. doi: 10.3389/fimmu.2022.816282. eCollection 2022.
Iron is a critical element for living cells in terrestrial life. Although iron metabolism is strictly controlled in the body, disturbance of iron homeostasis under certain type of condition leads to innate and adaptive immune response. In innate immunity, iron regulates macrophage polarizations, neutrophils recruitment, and NK cells activity. In adaptive immunity, iron had an effect on the activation and differentiation of Th1, Th2, and Th17 and CTL, and antibody response in B cells. In this review, we focused on iron and immune regulation and listed the specific role of iron in macrophage polarization, T-cell activation, and B-cells antibody response. In addition, correlations between iron and several diseases such as cancer and aging degenerative diseases and some therapeutic strategies targeting those diseases are also discussed.
铁是陆地生命中细胞的关键元素。尽管体内铁代谢受到严格控制，但在某些条件下铁稳态的紊乱会导致先天和适应性免疫反应。在先天免疫中，铁调节巨噬细胞极化、中性粒细胞募集和 NK 细胞活性。在适应性免疫中，铁对 Th1、Th2 和 Th17 以及 CTL 的激活和分化以及 B 细胞中的抗体反应有影响。在这篇综述中，我们重点介绍了铁与免疫调节，并列出了铁在巨噬细胞极化、T 细胞激活和 B 细胞抗体反应中的具体作用。此外，还讨论了铁与癌症和衰老退行性疾病等几种疾病之间的相关性以及针对这些疾病的一些治疗策略。
