Center for Iron Disorders, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA; email:
Annu Rev Med. 2023 Jan 27;74:261-277. doi: 10.1146/annurev-med-043021-032816. Epub 2022 Jul 29.
Hepcidin, the iron-regulatory hormone, determines plasma iron concentrations and total body iron content. Hepcidin, secreted by hepatocytes, functions by controlling the activity of the cellular iron exporter ferroportin, which delivers iron to plasma from intestinal iron absorption and from iron stores. Hepcidin concentration in plasma is increased by iron loading and inflammation and is suppressed by erythropoietic stimulation and during pregnancy. Hepcidin deficiency causes iron overload in hemochromatosis and anemias with ineffective erythropoiesis. Hepcidin excess causes iron-restrictive anemias including anemia of inflammation. The development of hepcidin diagnostics and therapeutic agonists and antagonists should improve the treatment of iron disorders.
亚铁调素是一种铁调节激素，决定着血浆铁浓度和体内铁总量。亚铁调素由肝细胞分泌，通过控制细胞铁输出蛋白 Ferroportin 的活性来发挥作用，后者将肠道铁吸收和铁储存中的铁输送到血浆中。血浆中亚铁调素浓度在铁负荷和炎症时增加，在促红细胞生成刺激和妊娠时降低。亚铁调素缺乏导致血色病和无效红细胞生成性贫血的铁过载。亚铁调素过多导致铁限制性贫血，包括炎症性贫血。亚铁调素诊断和治疗激动剂和拮抗剂的发展应改善铁代谢紊乱的治疗。
