Dawson P, Howell M
Br J Radiol. 1986 Oct;59(706):987-91. doi: 10.1259/0007-1285-59-706-987.
Non-ionic dimers are a new class of iodinated radiological contrast agents. Some physico-chemical and pharmacological properties of three representative compounds are presented. Non-ionic dimers are iso-osmolar with plasma at all iodine concentrations unless diluted with saline and in terms of chemotoxicity they appear to be closely comparable with the established non-ionic monomeric agents. It is shown that the data lend support to the theory that it is the degree of steric hindrance of the hydrophobic iodine atoms by side-chains which determines this chemotoxicity. Areas in which agents of this type may find applications are indicated.
非离子二聚体是一类新型的碘化放射造影剂。文中介绍了三种代表性化合物的一些物理化学和药理学性质。非离子二聚体在所有碘浓度下均与血浆等渗，除非用盐水稀释，就化学毒性而言，它们似乎与已有的非离子单体造影剂密切相当。结果表明，这些数据支持了这样一种理论，即侧链对疏水碘原子的空间位阻程度决定了这种化学毒性。文中指出了这类造影剂可能的应用领域。
