Chia Daryl K A, Demuytere Jesse, Ernst Sam, Salavati Hooman, Ceelen Wim
Department of Surgery, National University Hospital, National University Health System, Singapore 119074, Singapore.
Department of Human Structure and Repair, Experimental Surgery Lab, Ghent University, 9052 Ghent, Belgium.
Cancers (Basel). 2023 Aug 29;15(17):4314. doi: 10.3390/cancers15174314.
Hyperthermia combined with intraperitoneal (IP) drug delivery is increasingly used in the treatment of peritoneal metastases (PM). Hyperthermia enhances tumor perfusion and increases drug penetration after IP delivery. The peritoneum is increasingly recognized as an immune-privileged organ with its own distinct immune microenvironment. Here, we review the immune landscape of the healthy peritoneal cavity and immune contexture of peritoneal metastases. Next, we review the potential benefits and unwanted tumor-promoting effects of hyperthermia and the associated heat shock response on the tumor immune microenvironment. We highlight the potential modulating effect of hyperthermia on the biomechanical properties of tumor tissue and the consequences for immune cell infiltration. Data from translational and clinical studies are reviewed. We conclude that (mild) hyperthermia and HIPEC have the potential to enhance antitumor immunity, but detailed further studies are required to distinguish beneficial from tumor-promoting effects.
热疗联合腹腔内（IP）给药在腹膜转移瘤（PM）治疗中的应用日益广泛。热疗可增强肿瘤灌注，并在腹腔内给药后增加药物渗透。腹膜越来越被认为是一个具有自身独特免疫微环境的免疫特权器官。在此，我们综述了健康腹膜腔的免疫格局以及腹膜转移瘤的免疫背景。接下来，我们综述了热疗的潜在益处和不良的促肿瘤作用，以及相关的热休克反应对肿瘤免疫微环境的影响。我们强调了热疗对肿瘤组织生物力学特性的潜在调节作用及其对免疫细胞浸润的影响。对转化研究和临床研究的数据进行了综述。我们得出结论，（轻度）热疗和热灌注化疗有增强抗肿瘤免疫力的潜力，但需要进一步详细研究以区分有益作用和促肿瘤作用。
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