热休克蛋白在转移性结直肠癌中的作用：综述。

The role of heat shock proteins in metastatic colorectal cancer: A review.

机构信息

Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of ‎Medical Sciences, Mashhad, Iran.

Department of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.

出版信息

J Cell Biochem. 2022 Nov;123(11):1704-1735. doi: 10.1002/jcb.30326. Epub 2022 Sep 5.

DOI:10.1002/jcb.30326

PMID:36063530

Abstract

Heat shock proteins (HSPs) are a large molecular chaperone family classified by their molecular weights, including HSP27, HSP40, HSP60, HSP70, HSP90, and HSP110. HSPs are likely to have antiapoptotic properties and participate actively in various processes such as tumor cell proliferation, invasion, metastases, and death. In this review, we discuss comprehensively the functions of HSPs associated with the progression of colorectal cancer (CRC) and metastasis and resistance to cancer therapy. Taken together, HSPs have numerous clinical applications as biomarkers for cancer diagnosis and prognosis and potential therapeutic targets for CRC and its related metastases.

摘要

热休克蛋白（HSPs）是一个庞大的分子伴侣家族，根据其分子量进行分类，包括 HSP27、HSP40、HSP60、HSP70、HSP90 和 HSP110。HSPs 可能具有抗凋亡特性，并积极参与多种过程，如肿瘤细胞增殖、侵袭、转移和死亡。在这篇综述中，我们全面讨论了与结直肠癌（CRC）进展和转移以及癌症治疗耐药性相关的 HSPs 的功能。总之，HSPs 作为癌症诊断和预后的生物标志物以及 CRC 及其相关转移的潜在治疗靶点，具有广泛的临床应用。