上消化道和下消化道癌的细胞减灭术联合术中腹腔热灌注化疗应用综述
Cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy applications in upper and lower gastrointestinal cancer, a review.
作者信息
Drittone Denise, Schipilliti Francesca Matilde, Arrivi Giulia, Mazzuca Federica
机构信息
Medical Oncology Unit, Sant'Andrea Hospital in Rome, Rome, Italy.
Medical Oncology Unit, Azienda Sanitaria Locale Roma 5, Rome, Italy.
出版信息
Oncol Rev. 2024 Nov 26;18:1496141. doi: 10.3389/or.2024.1496141. eCollection 2024.
Abstract
Peritoneal metastases (PM) are the spread of tumor forms into the peritoneum as metastases from another organ. PM is a frequent condition in metastatic gastrointestinal cancer (colorectal, gastric, pancreatic, appendiceal, and cholangiocarcinoma); their presence confers a poor prognosis, reducing patient survival. The standard treatment consists of systemic chemotherapy according to current guidelines. In recent years, scientific evidence has shown how combined cytoreductive surgery (CRS) techniques followed by hyperthermic intraperitoneal chemotherapy (HIPEC) can improve survival in this patient population. Despite the results still obtained, using this combined technique is still under discussion. This review aims to highlight the benefits and limitations of this combined procedure, which is already widely used to treat peritoneal metastases in gynecological tumors.
摘要
腹膜转移（PM）是指肿瘤从其他器官转移至腹膜而形成的转移灶。PM在转移性胃肠道癌（结直肠癌、胃癌、胰腺癌、阑尾癌和胆管癌）中很常见；其存在预示着预后不良，会缩短患者生存期。标准治疗方法是根据当前指南进行全身化疗。近年来，科学证据表明，联合细胞减灭术（CRS）及随后的热灌注化疗（HIPEC）如何能够提高这类患者群体的生存率。尽管仍有研究结果，但这种联合技术的使用仍在讨论中。本综述旨在强调这种联合手术的益处和局限性，该手术已广泛用于治疗妇科肿瘤的腹膜转移。
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