Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Medical Examination Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Nutrients. 2023 Aug 24;15(17):3697. doi: 10.3390/nu15173697.
The relationship between vitamin D deficiency and sensitivity to thyroid hormones was unclear. We aimed to explore the association of 25-hydroxyvitamin D (25(OH)D) levels with thyroid hormone sensitivity in euthyroid adults. A total of 3143 subjects were included. The serum 25(OH)D, free thyroxine (FT3), free thyrotropin (FT4), thyroid-stimulating hormone (TSH), and other clinical variables were measured. Vitamin D deficiency was defined as 25(OH)D < 20 ng/mL. Thyroid feedback quantile-based index (TFQI), parametric thyroid feedback quantile-based index (PTFQI), thyroid-stimulating hormone index (TSHI), thyrotrophic thyroxine resistance index (TT4RI), and FT3/FT4 were calculated to assess thyroid hormone sensitivity. Results showed that 58.8% of the participants had vitamin D deficiency. They had significantly higher levels of triglyceride, insulin, FT3, FT4, TSH, TFQI, PTFQI, TSHI, and TT4RI and lower levels of high-density lipoprotein cholesterol than those with sufficient vitamin D (all < 0.05). Logistic regression analysis showed that the risk of impaired sensitivity to thyroid hormones evaluated by TFIQ, PTFQI, TSHI, and TT4RI increased by 68% (OR: 1.68; 95%CI: 1.45-1.95; and < 0.001), 70% (OR: 1.70; 95%CI: 1.46-1.97; and < 0.001), 66% (OR: 1.66; 95%CI: 1.43-1.92; and < 0.001), and 50% (OR: 1.50; 95%CI: 1.30-1.74; and < 0.001), respectively, in participants with vitamin D deficiency compared with those with sufficient vitamin D after adjusting for multiple confounders. In conclusion, in euthyroid populations, vitamin D deficiency was associated with impaired sensitivity to thyroid hormones.
维生素 D 缺乏与甲状腺激素敏感性之间的关系尚不清楚。我们旨在探讨 25-羟维生素 D（25(OH)D）水平与甲状腺功能正常成年人甲状腺激素敏感性之间的关系。共纳入 3143 例受试者。测量血清 25(OH)D、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、促甲状腺激素（TSH）和其他临床变量。维生素 D 缺乏定义为 25(OH)D<20ng/mL。计算甲状腺反馈定量指数（TFQI）、参数甲状腺反馈定量指数（PTFQI）、促甲状腺激素指数（TSHI）、甲状腺刺激素甲状腺素抵抗指数（TT4RI）和 FT3/FT4，以评估甲状腺激素敏感性。结果显示，58.8%的参与者存在维生素 D 缺乏。与维生素 D 充足者相比，他们的甘油三酯、胰岛素、FT3、FT4、TSH、TFQI、PTFQI、TSHI 和 TT4RI 水平显著升高，高密度脂蛋白胆固醇水平显著降低（均<0.05）。Logistic 回归分析显示，用 TFIQ、PTFQ、TSHI 和 TT4RI 评估的甲状腺激素敏感性受损风险增加 68%（OR：1.68；95%CI：1.45-1.95；和<0.001）、70%（OR：1.70；95%CI：1.46-1.97；和<0.001）、66%（OR：1.66；95%CI：1.43-1.92；和<0.001）和 50%（OR：1.50；95%CI：1.30-1.74；和<0.001），分别在维生素 D 缺乏的参与者与维生素 D 充足的参与者之间，调整了多种混杂因素后。总之，在甲状腺功能正常的人群中，维生素 D 缺乏与甲状腺激素敏感性受损有关。
