He Chen, Gao Qin, Ye Changwen, Yang Guotao, Zhang Pengfei, Yang Rongchao, Zhang Qing, Ma Kang
Zhengzhou Tobacco Research Institute of China National Tobacco Corporation, Zhengzhou 450001, China.
Division of Chemical Metrology and Analytical Science, National Institute of Metrology, Beijing 100013, China.
Molecules. 2023 Aug 25;28(17):6245. doi: 10.3390/molecules28176245.
Vinyl acetate is a restricted substance in food products. The quantification of the organic impurities in vinyl acetate is a major problem due to its activity, instability, and volatility. In this paper, while using the mass balance method to determine the purity of vinyl acetate, an improved method was established for the determination of the content of three impurities in vinyl acetate reference material, and the GC-FID peak area normalization for vinyl acetate was calibrated. The three trace organic impurities were identified by gas chromatography tandem high-resolution mass spectrometry to be methyl acetate, ethyl acetate, and vinyl propionate. The content and relative correction factors for the three organic impurities were measured. The purity of vinyl acetate determined by the mass balance method was 99.90% with an expanded uncertainty of 0.30%, and the total content of organic impurities was 0.08% with a relative correction factor of 1.23%. The vinyl acetate reference material has been approved as a national certified reference material in China as GBW (E) 062710.
醋酸乙烯酯是食品中的受限物质。由于其活性、不稳定性和挥发性，对醋酸乙烯酯中有机杂质的定量是一个主要问题。本文在采用质量平衡法测定醋酸乙烯酯纯度的同时，建立了一种改进的方法来测定醋酸乙烯酯标准物质中三种杂质的含量，并对醋酸乙烯酯的气相色谱 - 氢火焰离子化检测器（GC - FID）峰面积归一化进行了校准。通过气相色谱串联高分辨率质谱鉴定出三种痕量有机杂质为乙酸甲酯、乙酸乙酯和丙酸乙烯酯。测定了这三种有机杂质的含量和相对校正因子。采用质量平衡法测定的醋酸乙烯酯纯度为99.90%，扩展不确定度为0.30%，有机杂质总含量为0.08%，相对校正因子为1.23%。该醋酸乙烯酯标准物质已作为GBW (E) 062710在中国被批准为国家有证标准物质。
