Department of Clinical Sciences and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.
Laboratory of Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent University, Ghent, Belgium.
Immunol Cell Biol. 2023 Nov-Dec;101(10):936-946. doi: 10.1111/imcb.12688. Epub 2023 Sep 9.
Allergy is an ever-evolving group of disorders, which includes asthma, atopic dermatitis, rhinitis and food allergies and that currently affects over 1 billion people worldwide. This group of disorders has exploded in incidence since around the start of the 20th century, implying that genetics is not solely responsible for its development but that environmental factors have an important role. Here, Fabio Luciani and Jonathan Coquet, in their role as editors at Immunology & Cell Biology, asked nine prominent researchers in the field of allergy to define the term 'allergy', discuss the role of genetics and the environment, nominate the most important discoveries of the past decade and describe the best strategies to combat allergy at the population level going forward.
过敏是一组不断发展的疾病，包括哮喘、特应性皮炎、鼻炎和食物过敏，目前影响着全球超过 10 亿人。自 20 世纪初以来，这组疾病的发病率呈爆炸式增长，这意味着遗传因素并不是其发展的唯一原因，环境因素也起着重要作用。在这里，Fabio Luciani 和 Jonathan Coquet 作为《免疫与细胞生物学》的编辑，邀请了过敏领域的九位杰出研究人员来定义“过敏”一词，讨论遗传和环境的作用，提名过去十年最重要的发现，并描述在未来如何在人群层面上对抗过敏的最佳策略。
