大环内酯酯酶：当前的威胁与机遇。
Macrolide esterases: current threats and opportunities.
机构信息
Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada, S7N 5B4.
Department of Biochemistry, Microbiology, and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada, S7N 5E5.
出版信息
Trends Microbiol. 2023 Dec;31(12):1199-1201. doi: 10.1016/j.tim.2023.08.008. Epub 2023 Sep 8.
Antibiotics often contain ester bonds. The macrocyclic lactones of macrolides are pre-eminent examples in which ester bonds are essential to the form and function of antibiotics. Bacterial macrolide esterases that hydrolyze these macrocyclic lactones to confer antimicrobial resistance (AMR) are the topic of this forum. We provide insight into their role in agricultural systems and discuss their emergence and their potential extensibility to bioremediation efforts.
抗生素通常含有酯键。大环内酯类抗生素的大环内酯是其中的杰出范例，其中酯键对于抗生素的形式和功能至关重要。能够水解这些大环内酯以赋予抗生素耐药性（AMR）的细菌大环内酯酯酶是本次专题讨论的主题。我们深入探讨了它们在农业系统中的作用，并讨论了它们的出现及其在生物修复工作中的潜在可扩展性。
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