一个被忽视且新兴的抗生素耐药基因编码一种依赖丝氨酸的大环内酯酯酶。
A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase.
机构信息
Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada.
Department of Large Animal Clinical Sciences, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada.
出版信息
Proc Natl Acad Sci U S A. 2023 Feb 21;120(8):e2219827120. doi: 10.1073/pnas.2219827120. Epub 2023 Feb 15.
Abstract
The discovery of unreported antimicrobial resistance genes (ARGs) remains essential. Here, we report the identification and preliminary characterization of an α/β-hydrolase that inactivates macrolides. This serine-dependent macrolide esterase co-occurs with emerging ARGs in the environment, animal microbiomes, and pathogens.
摘要
发现未报告的抗菌药物耐药基因（ARGs）仍然至关重要。在这里，我们报告了一种能够使大环内酯类药物失活的 α/β-水解酶的鉴定和初步特征。这种丝氨酸依赖性的大环内酯酯酶与环境、动物微生物组和病原体中的新兴 ARGs 共同存在。
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