Sjölander A, Magnusson K E, Latkovic S
Cell Struct Funct. 1986 Sep;11(3):285-93. doi: 10.1247/csf.11.285.
Dietary lectins of gluten origin have been suggested to play an important role in the mechanisms leading to the characteristic morphology of the intestine found in patients with celiac disease. To further explore this issue we have used Wheat Germ Agglutinin (WGA) or Concanavalin A (Con A) to challenge rat small intestine and study the ultrastructural changes of such a treatment. Both lectins affected the enterocytes at the base of the villi more than those at the top. The morphological findings included disarrangement of the cytoskeleton, increased endocytosis and shortening of the microvilli. The interrelationship between the observed changes, and their relevance for similar morphological alterations found in patients with celiac disease are discussed. In conclusion, the morphological findings in our rat model resemble early changes in patients with celiac disease, thus supporting the idea that lectins or lectin-like substances are involved in the pathogenesis of this disease.
源自麸质的膳食凝集素被认为在导致乳糜泻患者肠道特征性形态的机制中起重要作用。为了进一步探讨这个问题，我们使用麦胚凝集素（WGA）或刀豆球蛋白A（Con A）对大鼠小肠进行刺激，并研究这种处理后的超微结构变化。两种凝集素对绒毛底部肠上皮细胞的影响比对顶部的影响更大。形态学发现包括细胞骨架排列紊乱、内吞作用增加和微绒毛缩短。本文讨论了观察到的变化之间的相互关系，以及它们与乳糜泻患者中发现的类似形态学改变的相关性。总之，我们大鼠模型中的形态学发现类似于乳糜泻患者的早期变化，因此支持了凝集素或凝集素样物质参与该疾病发病机制的观点。
