Centro de Investigación y de Estudios Avanzados del I.P.N-Unidad Monterrey, Vía del Conocimiento 201, Parque de Investigación e Innovación Tecnológica, 66600, Apodaca, NL, México.
Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Cátedra de Cardiología, Hospital Zambrano Hellion, TecSalud, San Pedro Garza García, México.
Sci Rep. 2023 Sep 9;13(1):14898. doi: 10.1038/s41598-023-41611-6.
Noise is present in cell biology. The capability of cells to respond to noisy environment have become essential. This study aimed to investigate whether noise can enhance the contractile response and Ca handling in cardiomyocytes from a cardiomyopathy model. Experiments were conducted in an experimental setup with Gaussian white noise, frequency, and amplitude control to stimulate myocytes. Cell shortening, maximal shortening velocity, time to peak shortening, and time to half relaxation variables were recorded to cell shortening. Ca transient amplitude and raise rate variables were registered to measure Ca transients. Our results for cell shortening, Ca transient amplitude, and raise rate suggest that cell response improve when myocytes are noise stimulated. Also, cell shortening, maximal shortening velocity, Ca transient amplitude, and raise improves in control cells. Altogether, these findings suggest novel characteristics in how cells improve their response in a noisy environment.
噪声存在于细胞生物学中。细胞对噪声环境做出反应的能力变得至关重要。本研究旨在探讨噪声是否可以增强心肌病模型中心肌细胞的收缩反应和钙处理能力。实验在具有高斯白噪声、频率和幅度控制的实验装置中进行，以刺激心肌细胞。记录细胞缩短、最大缩短速度、达到缩短峰值的时间和半松弛时间变量来测量细胞缩短。记录 Ca 瞬变幅度和上升率变量来测量 Ca 瞬变。我们对细胞缩短、Ca 瞬变幅度和上升率的结果表明，当心肌细胞受到噪声刺激时，细胞反应会改善。此外，对照细胞的细胞缩短、最大缩短速度、Ca 瞬变幅度和上升率也得到了改善。总的来说，这些发现表明细胞在噪声环境中改善其反应的方式具有新的特征。
