Division of Veterinary Parasitology, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Jammu and Kashmir 190006, India.
Division of Veterinary Parasitology, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Jammu and Kashmir 190006, India.
Res Vet Sci. 2023 Nov;164:105001. doi: 10.1016/j.rvsc.2023.105001. Epub 2023 Sep 4.
Development of anticoccidial resistance and concerns of drug residues have prompted the evaluation of alternatives to allopathic drugs. In current study, anticoccidial effect of amprolium was compared with that of Curcuma longa and Zingiber officinale. Ninety (90) sheep, naturally infected with Eimeria spp. and having a minimum oocyst per gram (OPG) count of faeces above 5000 were randomly selected and divided into six groups of 15 animals each. Animals were supplemented with amprolium @ 62.50 mg/kg body weight (bw) (GI), turmeric @ 200 and 300 mg/kg bw (GII and GIII) and ginger @ 200 and 300 mg/kg bw (GIV and GV), orally for 7 days and GVI animals were kept as untreated infected control. Faecal samples were collected on '0' day before treatment and on 8th, 14th, 21st and 28th day after starting treatment and evaluated using Faecal oocyst count reduction test (FOCRT). The efficacy of amprolium was 93.18%, 96.82%, 95.56% and 95.80% on 8th, 14th, 21st and 28th day, after starting treatment. Turmeric @200 mg/kg b.w. showed efficacy of 41.49%, 52.37%, 61.47% and 60.08% and turmeric @ 300 mg/kg bw was 44.92%, 54.32%, 64.21% and 61.95% effective on 8th, 14th, 21st and 28th day, respectively. Ginger @200 mg/kg bw showed efficacy of 38.51%, 53.48%, 55.38% and 55.53% and ginger @ 300 mg/kg bw was 39.65%, 54.81%, 57.18% and 58.22% effective on 8th,14th, 21st and 28th day, respectively. The results justify use of amprolium for clinical coccidiosis while Curcuma longa and Gingiber officinale could be used as natural prophylactic alternatives.
抗球虫药耐药性的发展和药物残留问题引起了人们对替代全化学疗法药物的关注。在本研究中，比较了氨丙啉、姜黄和生姜对球虫病的防治效果。选择 90 只自然感染艾美尔球虫且粪便每克卵囊数（OPG）超过 5000 的绵羊，随机分为 6 组，每组 15 只。动物每天口服补充氨丙啉 62.50mg/kg 体重（GI）、姜黄 200 和 300mg/kg 体重（GII 和 GIII）和生姜 200 和 300mg/kg 体重（GIV 和 GV），连续 7 天，GVI 组为未处理的感染对照组。在治疗前的“0”天、治疗开始后的第 8、14、21 和 28 天收集粪便样本，并使用粪便卵囊计数减少试验（FOCRT）进行评估。氨丙啉在治疗开始后第 8、14、21 和 28 天的疗效分别为 93.18%、96.82%、95.56%和 95.80%。姜黄 200mg/kg 体重的疗效分别为 41.49%、52.37%、61.47%和 60.08%，姜黄 300mg/kg 体重的疗效分别为 44.92%、54.32%、64.21%和 61.95%。生姜 200mg/kg 体重的疗效分别为 38.51%、53.48%、55.38%和 55.53%，生姜 300mg/kg 体重的疗效分别为 39.65%、54.81%、57.18%和 58.22%。结果表明，氨丙啉可用于临床球虫病，而姜黄和生姜可作为天然预防替代品。
