Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
Neurosciences Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Acta Neuropsychiatr. 2024 Jun;36(3):139-152. doi: 10.1017/neu.2023.42. Epub 2023 Sep 11.
Major depressive disorder (MDD) is one of the leading causes of disability. We aimed to report the MDD-attributable prevalence, incidence and years lived with disability (YLDs) in the Middle East and North Africa (MENA) region from 1990 to 2019 by age, sex and socio-demographic index (SDI).
Publicly available data on the burden of MDD were retrieved from the Global Burden of Disease (GBD) study 2019 for the 21 countries in MENA. The counts and age-standardised rates (per 100,000) were presented, along with their corresponding 95% uncertainty intervals.
In 2019, MDD had an age-standardised point prevalence of 3322.1 and an incidence rate of 4921.7 per 100,000 population in MENA. Furthermore, there were 4.1 million YLDs in 2019. However, there were no substantial changes in the MDD burden over the period 1990-2019. In 2019, Palestine had the highest burden of MDD. The highest prevalence, incidence and YLDs attributable to MDD were found in the 35-39 age group. In 2019, the YLD rate in MENA was higher than the global rate for almost all age groups. Furthermore, there was a broadly negative association between the YLD rate and SDI.
The study highlights the need to prevent the disorder using a multidisciplinary approach and for the provision of cost-effective treatments for those affected, in order to increase their quality of life.
重度抑郁症（MDD）是导致残疾的主要原因之一。我们旨在报告 1990 年至 2019 年期间中东和北非（MENA）地区按年龄、性别和社会人口指数（SDI）划分的 MDD 归因患病率、发病率和残疾年数（YLDs）。
从 2019 年全球疾病负担（GBD）研究中检索到 21 个 MENA 国家 MDD 负担的公开数据。呈现了数量和年龄标准化率（每 10 万人），以及相应的 95%置信区间。
2019 年，MENA 地区 MDD 的年龄标准化时点患病率为 3322.1，发病率为每 10 万人 4921.7。此外，2019 年有 410 万 YLDs。然而，1990-2019 年期间 MDD 负担没有实质性变化。2019 年，巴勒斯坦的 MDD 负担最重。35-39 岁年龄组的 MDD 患病率、发病率和 YLDs 最高。2019 年，MENA 的 YLD 率高于全球几乎所有年龄组的 YLD 率。此外，YLD 率与 SDI 之间存在广泛的负相关。
该研究强调需要采用多学科方法预防这种疾病，并为受影响者提供具有成本效益的治疗方法，以提高他们的生活质量。
