Tovar J A, Morras I, Arana J, Garay J, Tapia I
Chir Pediatr. 1986;27(3):134-7.
Aiming to evaluate the participation of oesophageal motor troubles in the pathogeny of gastro-oesophageal reflux in brain-damaged children, we have studied 16 of these patients. Most of them had a more or less severe esophagitis due to excessive acid exposure. We have found a decreased LESP as compared to normal subjects (8.84 +/- 6.20 vs. 18.33 +/- 6.55 mmHg (p less than 0.001)), and high percentages of non-propulsive waves in basal conditions (70 +/- 29.66 vs. 6.25 +/- 9.16 (p less than 0.001)) as well as after serum (66.33 +/- 28.06 vs. 16.66 +/- 13.66 (p less than 0.001) and acid instillation (58.33 +/- 28.91 vs. 26.41 +/- 12.04 (p less than 0.05)). These results demonstrate that motor disturbances are responsible for the severity of GER in this group of patients.
为了评估食管运动障碍在脑损伤儿童胃食管反流发病机制中的作用，我们对16例此类患者进行了研究。他们中的大多数因酸暴露过多而患有程度不一的食管炎。我们发现，与正常受试者相比，这些患者的下食管括约肌压力降低（8.84±6.20 mmHg对18.33±6.55 mmHg，p<0.001），基础状态下非推进性波的百分比很高（70±29.66对6.25±9.16，p<0.001），血清刺激后（66.33±28.06对16.66±13.66，p<0.001）以及酸灌注后也是如此（58.33±28.91对26.41±12.04，p<0.05）。这些结果表明，运动障碍是导致该组患者胃食管反流严重程度的原因。
