Ohgaki H, Hasegawa H, Suenaga M, Kato T, Sato S, Takayama S, Sugimura T
Carcinogenesis. 1986 Nov;7(11):1889-93. doi: 10.1093/carcin/7.11.1889.
2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), a potent mutagen which was isolated from grilled sardines, was tested for carcinogenicity in CDF1 mice. Mice were given diet containing 0.04 or 0.01% MeIQ for 91 weeks. The incidences of liver tumors (hepatocellular carcinomas and hepatocellular adenomas) in female mice given 0.04 and 0.01% MeIQ were significantly higher than those in controls. The incidences of forestomach tumors (squamous cell carcinomas and papillomas) were also significantly higher in both sexes of mice given MeIQ. About 40% of the squamous cell carcinomas that developed in mice given diet containing 0.04% MeIQ metastasized to the liver.
2-氨基-3,4-二甲基咪唑并[4,5-f]喹啉（MeIQ）是一种从烤沙丁鱼中分离出的强效诱变剂，对其进行了CDF1小鼠致癌性测试。给小鼠喂食含0.04%或0.01% MeIQ的饲料，持续91周。喂食0.04%和0.01% MeIQ的雌性小鼠肝脏肿瘤（肝细胞癌和肝细胞腺瘤）的发生率显著高于对照组。喂食MeIQ的雌雄小鼠前胃肿瘤（鳞状细胞癌和乳头状瘤）的发生率也显著更高。喂食含0.04% MeIQ饲料的小鼠中发生的鳞状细胞癌约40%转移至肝脏。
